Short CV
1977 | BSc (Hons), Physiology and Biochemistry, University of Reading. |
1983 | PhD, Department of Neuropathology, Institute of Psychiatry, Faculty of Medicine, University of London. |
1993 | MRCPath. |
2001 | FRCPath |
2008-present | Head of the Research Department of Cell Biology, Institute of Ophthalmology. |
My main scientific interests are retinal/brain vascular biology and RPE cell biology. The role of the blood-retina barrier plays in recruiting immune cells, the factors controlling vascular pathology, and the role of RPE cells in retinal degeneration constitute the principle focus of my research activity.
- Association for Research in Vision and Ophthalmology (ARVO)
John Greenwood |
Contact
UCL Institute of Ophthalmology
11-43 Bath Street
London SE5 8BN
United Kingdom
Phone: +44 (0)2076086858
Email:
j.greenwood[at]ucl.ac.uk
Key Publications
- Turowski, P., Martinelli, R., Crawford, R., Wateridge, D., Papagiorgiou, A-P., Lampugnani, M.G., Gamp, A., Vestweber, D., Adamson, P., Dejana, E. and Greenwood, J. (2008).
Phosphorylation of vascular endothelial cadherin controls lymphocyte emigration.
J. Cell Sci. 121:29-37.
- Coffey, P.J., Gias, C., McDermott, C.J., Lundh, P., Pickering, M.C., Sethi, C., Bird, A.,. Fitzke, F.W., Maass, A., Holder, G.E., Luthert, P.J., Salt, T.E., Moss, S.E. and Greenwood, J. (2007).
Complement factor H-deficiency in aged mice causes retinal abnormalities and visual dysfunction.
Proc. Natl. Acad. Sci. USA 104:16651-16656.
- Greenwood, J. and Mason, J.C. (2007).
Statins and the vascular endothelial inflammatory response.
Trends Immunol. 28: 88-98.
- Greenwood, J., Steinman, L. and Zamvil, S.S. (2006).
Statin therapy and autoimmune disease: from protein prenylation to immunomodulation.
Nat. Rev. Immunol. 6: 358-370.
- Gegg, M., Harry, R., Hankey, D., Zambarakji, H., Pryce, G., Baker, D., Adamson, P., Calder, V. and Greenwood, J. (2005).
Suppression of autoimmune retinal disease by lovastatin does not require TH2 cytokine induction.
J. Immunol. 174:2327-2335.
- Turowski, P., Adamson, P., Sathia, J., Zhang, J.J., Moss, S.E., Aylward, G.W., Hayes, M.J,, Kanuga, N. and Greenwood, J. (2004).
Basement membrane-dependent modification of phenotype and gene expression in the human retinal pigment epithelial cell line ARPE-19.
Invest. Ophthalmol. Vis. Sci . 45:2786-2794.
- Greenwood, J., Amos, C.L., Walters, C.E., Couraud, P-O., Lyck, R., Engelhardt, B. and Adamson, P. (2003).
Intracellular domain of brain endothelial ICAM-1 is essential for T-lymphocyte-mediated signalling and migration.
J. Immunol. 171:2099-2108.
- Greenwood, J., Walters, C.E., Pryce, G., Kanuga, N., Beraud, E., Baker, D., and Adamson, P. (March 5, 2003).
Lovastatin inhibits brain endothelial Rho-dependent lymphocyte migration and attenuates experimental autoimmune encephalomyelitis.
FASEB J. On line. 10.1096/fj.02-1014fje.
- Coffey, P.J., Girman, S., Wang, S.M., Hetherington, L., Keegan, D.J., Adamson, P., Greenwood, J. and Lund, R.D. (2002).
Long-term preservation of cortically dependent visual function in dystrophic RCS rats by transplantation of immortalized retinal pigment epithelial cells.
Nat. Neurosci. 5:53-56.
- Lund, R.D., Adamson, P. Sauvé, Y., Girman, S.V., Keegan, D., Winton, H., Kwan, A., Beauchene, L., Zerbib, A., Hetherington, L., Couraud, P.O., Coffey, P. and Greenwood, J. (2001).
Subretinal transplantation of a genetically engineered human RPE cell line prevents visual loss in the RCS rat.
Proc. Natl. Acad. Sci. USA 98:9942-9947.
Research Groups
People