David Hicks is principal investigator and full professor at the INSERM U.592, Strasbourg, France.
Short CV
1974-77 | BsC Zoology (Hons.), Univ. Bristol, UK |
1978-81 | PhD Developmental Neurobiology, Woolwich Univ., London UK |
1981-84 | Postdoctoral Student, Dept. Biochem., Univ. B.C., Vancouver, B.C., Canada |
1984-87 | Postdoctoral Fellow, Lab. Neurobiol., Rockefeller Univ., New York, NY USA. |
1987-88 | Visiting Scientist, INSERM U.118, Paris, France |
1988-92 | Assistant Professor (Chargé de Recherche) INSERM, INSERM U.118, Paris, France. |
1992-2004 | Full Professor (Directeur de Recherche) INSERM, INSERM U.592, Strasbourg, France |
2004-present | Full Professor, CNRS UMR 7168/LC2, INCI, Strasbourg, France |
- Cellular localisation and molecular mechanisms underlying rod photoreceptor circadian biology.
- Role of circadian clock genes in retinal function and pathological consequences of clock perturbation.
- Cone photoreceptor phagocytosis in cone-rich rodents and humans: circadian regulation, normal aging and age-related macular degeneration.
- Experimental cone degeneration and neuroprotection: generation of transgenic cone-rich rodent models of human inherited retinal disease.
- Experimental cone degeneration and neuroprotection: light- and drug-induced breakdown in cone-rich animal models of human vision.
- Early changes in diabetic retinopathy: structural and functional studies using novel animal models.
- Association for Research in Vision and Ophthalmology (ARVO)
- Société Française de Chronobiologie
- International Society for Eye research
Further Activities
- Director, “Research Project” module, Joint Masters in Neuroscience, Univ. Louis Pasteur, Strasbourg, France.
- Editorial Board Member, Investigative Ophthalmology & Visual Science.
- Editorial Board Member, Journal of Ocular Biology, Diseases and Informatics.
- Scientific Committee Member, Retina France.
- Editorial Board Member, Graefe's Archives for Clinical and Experimental Ophthalmology.
Research Group
Circadian clocks and retinal pathophysiology
Key Publications
- Saïdi T, Mbarek S, Chaouacha-Chekir RB, Hicks D. (2011)
Diurnal rodents as animal models of human central vision: characterisation of the retina of the sand rat Psammomys obsesus.
Graefes Arch Clin Exp Ophthalmol. 249: 1029-37. - Saïdi T, Mbarek S, Omri S, Behar-Cohen F, Chaouacha-Chekir RB, Hicks D. (2011)
The Sand Rat Psammomys obesus develops Type 2 Diabeic retinopathy Similar to Humans.
Invest Ophthalmol Vis Sci. 52: 8993-9004. - Boudard DL, Acar N, Bretillon L, Hicks D. (2011)
Retinas of the Diurnal Rodent Arvicanthis ansorgei Are Highly Resistant to Experimentally Induced Stress and Degeneration.
Invest Ophthalmol Vis Sci. 52: 8686-700. - Sandu C, Hicks D, Felder-Schmittbuhl MP. (2011)
Rat photoreceptor circadian oscillator strongly relies on lighting conditions.
Eur J Neurosci. 34: 507-16. - Verra DM, Contín MA, Hicks D, Guido ME. (2011)
Early onset and differential temporospatial expression of melanopsin isoforms in the developing chicken retina.
Invest Ophthalmol Vis Sci. 52: 5111-20. - Hicks D. (2011)
Second sight?
Graefes Arch Clin Exp Ophthalmol. 249: 313-4. - Krigel A, Felder-Schmittbuhl MP, Hicks D. (2010)
Circadian-clock driven cone-like photoreceptor phagocytosis in the neural retina leucine zipper gene knockout mouse.
Mol Vis. 16: 2873-81. - Sparrow JR, Hicks D, Hamel C. (2010)
Retinal pigmented epithelium in health and disease.
Curr Mol Med. 10: 802-23 . - Mehdi MK, Hicks D. (2010)
Structural and physiological responses to prolonged constant lighting in the cone-rich retina of Arvicanthis ansorgei.
Exp Eye Res. 91: 793-9. - Boudard DL, Tanimoto N, Huber G, Beck SC, Seeliger MW, Hicks D. (2010)
Cone loss is delayed relative to rod loss during induced retinal degeneration in the diurnal cone-rich rodent Arvicanthis ansorgei.
Neuroscience. 169: 1815-30. - Boudard DL, Mendoza J, Hicks D. (2009)
Loss of photic entrainment at low illuminances in rats with acute photoreceptor degeneration.
Eur J Neurosci. 30:1527-36. - Bobu C, Hicks D. (2009)
Regulation of retinal photoreceptor phagocytosis in a diurnal mammal by circadian clocks and ambient lighting.
Invest Ophthalmol Vis Sci. 50:3495-502. - Tezcaner A, Hicks D. (2008)
In vitro characterization of micropatterned PLGA-PHBV8 blend films as temporary scaffolds for photoreceptor cells.
J Biomed Mater Res A. 86:170-81. - Siffroi-Fernandez S, Felder-Schmittbuhl MP, Khanna H, Swaroop A, Hicks D. (2008)
FGF19 exhibits neuroprotective effects on adult photoreceptors in vitro.
Invest Ophthalmol Vis Sci. 49: 1696-704. - Bobu C, Lahmam M, Vuillez P, Ouarour A, Hicks D. (2008)
Photoreceptor organisation and phenotypic characterization in retinas of two diurnal rodent species: potential use as experimental animal models for human vision research.
Vision Res. 48: 424-32.
Research Groups
People