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Our research is dedicated to decipher the intracellular signals involved in cell survival and cell death in inherited retinal diseases including Leber congenital amaurosis (LCA). Human RPE65-mediated LCA is a rod-cone dystrophy characterized by severe retinal defects in the first decades of life, mostly attributed to the loss of rod and cone photoreceptors.
While light-independent residual phototransduction cascade triggers Bax-dependent rod apoptosis, the nature of cone dysfunction still remains unknown. Identification of the molecular mechanisms in retinal cell death will contribute to a better understanding of the pathogenesis of retinal degeneration and to the development of novel molecular therapeutic approaches.
Sandra Cottet
[more information]
Avenue Grand-Champsec 64
1950 Sion
Switzerland
Phone: +41 (0)27 205 79 06
Fax: +41 (0)27 205 79 01
E-mail:
sandra.cottet[at]irovision.ch
Website:
www.irovision.ch