Short CV
1983 - 1989 | Medical School, University of Heidelberg, Germany |
1988 | University of Chicago Pritzker School of Medicine, Chicago, U.S.A. Subinternships in surgery and internal medicine Former scholar of the German National Scholarship Foundation („Studienstiftung des Deutschen Volkes“) |
1992 – 1993 | Research and Clinical Fellowship Medical Retina, Institute of Ophthalmology, Moorfields Eye Hospital, London, England, Supervisor: Professor Alan C. Bird, MD, FRCS, FRCOphth |
1995 – 2003 | „Oberarzt“ at the Department of Ophthalmology, University of Heidelberg, Germany; 2001-2003 „Geschäftsführender Oberarzt“ |
Since 2003 | Chairman and Professor, Department of Ophthalmology, University of Bonn |
- Pathogenesis, prognostic factors, biomarkers and treatment of age-related macular degeneration (AMD)
- Phenotyping retinal diseases by innovative imaging technologies including confocal scanning laser ophthalmoscopy and spectral domain optical coherence tomography imaging
- Development and implementation of molecular imaging for macular and retinal diseases
- Cell biology of retinal pigment epithelial cells in atrophic and neovascular ocular diseases
- Clinical trials and innovative therapies for the treatment of macular diseases, especially wet and dry age-related macular degeneration
- Association for Research in Vision and Ophthalmology (ARVO)
- American Academy of Ophthalmology
- Macula Society
- Club Jules Gonin
- Deutsche Ophthalmologische Gesellschaft (DOG)
- Euretina
- German Retinological Society
- European Fluorescein-Angiography Club (FAN-Club)
- Oxford Ophthalmological Congress (OOC)
Further Activities
- President of the German Society of Ophthalmology (DOG) 2007/2008
- Member of the Scientific Advisory Board AMD Alliance International
- Member of the Scientific Advisory Board Pro Retina Germany
- Editor-in-Chief ‚Der Ophthalmologe’, Springer; Organ of the German Ophthalmological Society (DOG)
- Editorial board member: Retina, International Ophthalmology, Graefe’s Archive of Clinical and Experimental Ophthalmology, Der Augenspiegel
Research Group
Imaging, pathogenesis and treatment of retinal/macular diseases
Key Publications
- Fleckenstein M, Charbel Issa P, Helb HM, Schmitz-Valckenberg S, Finger RP, Scholl HP, Loeffler KU, Holz FG.
High-resolution spectral domain-OCT imaging in geographic atrophy associated with age-related macular degeneration.
Invest Ophthalmol Vis Sci 2008;49:4137-44
- Helb HM, Charbel Issa P, van der Veen RL, Berendschot TT, Scholl HP, Holz FG..
Abnormal macular pigment distribution in type 2 idiopathic macular telangiectasia.
Retina 2008;28:808-16
- Holz FG, Bindewald-Wittich A, Fleckenstein M, Dreyhaupt J, Scholl HP, Schmitz-Valckenberg S;
FAM-Study Group. Progression of geographic atrophy and impact of fundus autofluorescence patterns in age-related macular degeneration.
Am J Ophthalmol 2007;143:463-72
- F.G. Holz, C. Bellmann, S. Staudt, F. Schütt, H.E. Völcker:
Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration.
Investigative Ophthalmology and Visual Science 2001;42:1051-6
- M. Bergmann, F. Schütt, F. G. Holz, J. Kopitz:
Inhibition of the ATP-driven proton pump in RPE lysosomes by the major lipofuscin fluorophor A2-E may contribute to the pathoegnesis of age-related macular degeneration.
FASEB J 2004;18:562-4
- Bindewald-Wittich A, Han M, Schmitz-Valckenberg S, Snyder SR, Giese G, Bille JF, Holz FG.
Two-Photon–Excited Fluorescence Imaging of Human RPE Cells with a Femtosecond Ti:Sapphire Laser.
Invest Ophthalmol Vis Sci. 2006;47:4553-57
- Scholl HP, Charbel Issa P, Walier M, Janzer S, Pollok-Kopp B, Börncke F, Fritsche LG, Chong NV, Fimmers R, Wienker T, Holz FG, Weber BH, Oppermann M.
Systemic complement activation in age-related macular degeneration.
PLoS ONE 2008;3(7):e2593.
- F.G. Holz, F. Schütt, J. Kopitz, G.E. Eldred, F.E. Kruse, H.E. Völcker, M. Cantz:
Inhibition of lysosomal degradative functions in RPE cells by a retinoid component of lipofuscin.
Investigative Ophthalmology and Visual Science 1999;40:734-7
- F.G. Holz, T.J. Wolfensberger, B. Piguet, M. Gross-Jendroska, J.A. Wells, D.C. Minassian, I.H. Chisholm, A.C. Bird:
Bilateral macular drusen in age-related macular degeneration: Prognosis and Risk Factors.
Ophthalmology 1994;101:1522-28
- F.G. Holz, K. Evans, C.Y. Gregory, S. Bhattacharya, A. C. Bird:
Autosomal dominant macular dystrophy simulating north carolina macular dystrophy.
Archives of Ophthalmology 1995;113:178-184
Research Groups
People