Short CV
I studied Physics and Biophysics at the University of Parma (Italy) and Lund (Sweden). I obtained a PhD in Biotechnology and Molecular Medicine from the University of Modena and Reggio Emilia (Italy). During my pre- and post-doctoral activity I visited several laboratories in Sweden and in Germany, to improve my knowledge of computational and experimental biophysical chemistry and systems biology. I have been A. von Humboldt Research Fellow at the University of Oldenburg (Germany) for almost 2.5 years. Since December 2011 I am Assistant Professor at the University of Verona, at the Biological Chemistry section of the Medical Faculty.
On a regular basis I act as a referee for several peer-review journals in the fields of Biochemistry, Biophysical Chemistry, Systems Biology and biology-oriented nanoscience, among which:
- Molecular Biosystems, Journal of Physical Chemistry B, PhysChemChemPhys, BBA-Proteins and Proteomics, PLoS Computational Biology, Integrative Biology, Cellular and Molecular Life Sciences, BioMaterials, ACS Nano, PLoS One, BioSystems
I teach Bioinformatics to undergraduate students in the bioinformatics and Biotechnology programs at the University of Verona.
Daniele Dell'Orco |
Research Group
Biophysical Chemistry and Systems Biology of Vision
[more information]
- Experimental and theoretical characterization of protein-protein and protein-ion interactions involved in vertebrate vision
- Biochemical mechanisms underlying complex photoreceptor cell behaviours in normal and disease-associated conditions
- Calcium binding and calcium sensor proteins: biophysical properties and dynamics
- Systems biology of signal transduction pathways and kinetic modeling
- nanoparticle-protein interactions and perturbation of biochemical pathways exerted by nanodevices
- Biochemical Society (UK)
- Italian society of Biochemistry and Molecular Biology (SIB)
- Bioinformatics Italian Society (BITS)
Key Publications
- Karl-Wilhelm Koch, Daniele Dell'Orco
A Calcium-Relay Mechanism in Vertebrate Phototransduction.
ACS Chemical Neuroscience 4: 6. 909–917 (2013) - Patrick Zägel, Daniele Dell'Orco, Karl-Wilhelm Koch
The Dimerization Domain in Outer Segment Guanylate Cyclase Is a Ca(2+)-Sensitive Control Switch Module.
Biochemistry (in press) (2013) - Brandon M Invergo, Ludovica Montanucci, Karl-Wilhelm Koch, Jaume Bertranpetit, Daniele Dell'Orco
Exploring the rate-limiting steps in visual phototransduction recovery by bottom-up kinetic modeling.
Cell communication and signaling: CCS 11: 1. 05 (2013) - Lorenzo Cangiano, Daniele Dell'Orco
Detecting single photons: A supramolecular matter?
FEBS Lett 587: 1. 1-4 (2013) - Daniele Dell'Orco
A physiological role for the supramolecular organization of rhodopsin and transducin in rod photoreceptors.
FEBS letters 587: 13. 2060-2066 (2013) - Simona Mariani, Daniele Dell'Orco, Angelo Felline, Francesco Raimondi, Francesca Fanelli
Network and atomistic simulations unveil the structural determinants of mutations linked to retinal diseases.
PLoS Comp Biol (in press) (2013) - Daniele Dell'Orco, Martin Lundqvist, Tommy Cedervall, Sara Linse
Delivery success rate of engineered nanoparticles in the presence of the protein corona: a systems-level screening.
Nanomedicine 8: 8. 1271-1281 (2012) - Daniele Dell'Orco, Karl-Wilhelm Koch
A dynamic scaffolding mechanism for rhodopsin and transducin interaction in vertebrate vision.
Biochem J 440: 2. 263-271 (2011) - Daniele Dell'Orco, Petra Behnen, Sara Linse, Karl-Wilhelm Koch
Calcium binding, structural stability and guanylate cyclase activation in GCAP1 variants associated with human cone dystrophy.
Cell Mol Life Sci 67: 6. 973-984 (2010) - Daniele Dell'Orco, Henning Schmidt, Simona Mariani, Francesca Fanelli
Network-level analysis of light adaptation in rod cells under normal and altered conditions.
Mol Biosyst 5: 10. 1232-1246 (2009)
Research Groups
People