Current Research Projects
Developing the application of Raman spectroscopy in the non-invasive detection of early stage age related macular degeneration. Raman spectroscopy is a non-destructive, non-invasive laser based method, currently used to measure carotenoid levels in-vivo in the fovea. I am developing a modified Raman spectrometer capable of measuring advanced glycation and lipoxidation endproducts on the collagens of the Bruch’s membrane and sclera.
Methodology
- Non-resonant Raman Spectroscopy
- Principal Component Analysis/ Singular Value Decomposition
- Partial-least Squares Regression
- Discriminant Analysis
- Developing novel noise-insensitive data processing methodologies
Selected Publications
- Beattie, J.R., Glenn, J.V., Boulton, M.E., Stitt, A.W., and McGarvey, J.J.
Effect of signal intensity normalization on the multivariate analysis of spectral data in complex ‘real-world’ datasets.
J. Raman Spectrosc. (2009) 40, p. 429-435. - Pawlak, A.M., Glenn, J.V., Beattie, J.R., McGarvey, J.J., and Stitt, A.W
Advanced glycation as a basis for understanding retinal aging and non-invasive risk prediction. Maillard Reaction: Recent Advances in Food and Biomedical Sciences.
NYNAS (2008) 1126, p. 59-65 - Pawlak, A.M., Beattie, J.R., Glenn, J.V., Stitt, A.W., McGarvey, J.J.
Raman spectroscopy of advanced glycation end products (AGEs), possible markers for progressive retinal dysfunction.
J Raman Spec. (2008) 39, 1635-1642. - Glenn J.V., Beattie J.R.*, Barrett L.J., Frizzell N., Thorpe S.R., Boulton M.E., McGarvey J.J., Stitt A.W.
Confocal Raman microscopy can quantify advanced glycation endproduct (AGE) modifications in Bruch’s membrane leading to accurate, non-destructive prediction of ocular aging.
FASEB J. (2007) 21, 3542-3552 - Beattie, J.R., Brockbank, S., McGarvey, J.J., Curry, W.J.
Raman microscopy of porcine inner retinal layers from the area centralis.
Mol Vis (2007) 13, 1106-1113 - Beattie, J. R., Brockbank, S., McGarvey, J. J. & Curry, W. J.
Effect of excitation wavelength on the Raman spectroscopy of the porcine photoreceptor layer from the area centralis.
Molecular Vision (2005) 11, 825-832
Renwick Beattie |
Research Group
Centre for Vision and Vascular Science
Contact
Queen's University Belfast
School of Medicine, Dentistry & Biomedical Science
Royal Victoria Hospital
BT12 6BA Belfast
United Kingdom
Phone: 028-90635072
E-mail:
r.beattie[at]qub.ac.uk
Research Groups
People