Short CV
1981 | Ms. Sc. Universidad Autónoma de Madrid |
1984 | Ph. D. Universidad Autónoma de Madrid. Centro de Biología Molecular, CSIC-UAM |
Post-doctoral positions: |
1984-1985 | Centro de Biología Molecular, CSIC-UAM |
1986-1989 | Max-Planck Institute for Developmental Biology, Tübingen (Germany), under Alexander-von-Humboldt Foundation Program |
1989-1992 | Instituto Cajal, CSIC |
1992-1993 | Centro de Investigaciones Biológicas, CSIC |
Staff scientist: |
1993 | Científico Titular, Centro de Investigaciones Biológicas, CSIC |
2002 | promoted to Investigador Científico, Centro de Biología Molecular, CSIC-UAM |
Visiting Scientist: |
1993 | Developmental Endocrinology Branch, NIH, Bethesda (USA) |
2003 | Wilmer Eye Institute, Johns Hopkins University, Baltimore (USA) |
- To understand the functional basis of programmed cell death during retinal/neural development.
- To understand the role of DNA repair during retinal/neural development.
- To attenuate the progression of retinal dystrophies.
- To understand subtle molecular and celular changes associated to retinal aging.
- Association for Research in Vision and Ophthalmology (ARVO)
- SfN
Spanish Societies
Enrique De la Rosa |
Research Group
3D Lab (Development, Differentiation and Degeneration)
[more information]
Contact
Centro de Investigaciones Biológicas
Consejo Superior de Investigaciones Científicas
C/ Ramiro de Maeztu 9
E-28040 Madrid
Spain
Phone: 34/918373112, ext 4375
FAX: 34/915360432
Email:
ejdelarosa[at]cib.csic.es
Website
http://www.cib.csic.es
Key Publications
- DNA-PK promotes the survival of young neurons in the embryonic mouse retina.
J. Baleriola, T. Suárez and , E.J. de la Rosa (2010)
Cell Death Differ 17, 1697-1706. - The autophagic machinery is necessary for removal of cell corpses from the developing retinal neuroepithelium.
M.A. Mellén, E. J. de la Rosa and P. Boya (2008).
Cell Death Differ 15,1279-1290 . - Differential, age-dependent MEK-ERK and PI3K-Akt activation by insulin acting as a survival factor during embryonic retinal development.
T. Chavarría, A. I. Valenciano, R. Mayordomo, J. Egea, J. X. Comella, F. Hallböök, F. de Pablo and E. J. de la Rosa (2007).
Dev. Neurobiol. 67, 1777-1788. - Proinsulin/insulin is synthesized locally and prevents caspase- and cathepsin-mediated cell death in the embryonic mouse retina.
A. I. Valenciano, S. Corrochano, F. de Pablo, P. de la Villa and E. J. de la Rosa (2006).
J. Neurochem 99, 524-536. - Balance of pro-apoptotic TGF-β and anti-apoptotic insulin effects in the control of cell death in the developing mouse retina.
N. Duenker, A. I. Valenciano, A. Franke, C. Hernández-Sánchez, R. Dressel, M. Behrendt, F. de Pablo, K. Krieglstein and E. J. de la Rosa (2005).
Eur. J. Neurosci 22, 28-38. - IGF-I maintains calpastatin expression and attenuates apoptosis in several models of photoreceptor cell death.
A. I. Arroba, D. Wallace, A. Mackey, E. J. de la Rosa# and T. G. Cotter# (#, contributing equally) (2009) Eur J Neurosci 30, 975-986. - Vimentin isoform expression in the human retina characterized with the monoclonal antibody 3CB2.
M. J. Pérez-Álvarez, C. Isiegas, C. Santano, J. J. Salazar, A. I. Ramírez, A. Triviño, J. M. Ramírez, J. P. Albar, E. J. de la Rosa and C. Prada (2008).
J Neurosci Res 86, 1871-1883. - Functional and structural modifications during retinal degeneration in the rd10 mouse.
R. Barhoum, G. Martínez-Navarrete, S. Corrochano, F. Germain, L. Fernández-Sánchez, E. J. de la Rosa, P. de la Villa and N. Cuenca (2008). Neuroscience 155, 698-713. - Apoptosis in the trabecular meshwork of glaucomatous patients.
J. Baleriola, J. García-Feijoo, J. M. Martínez-de-la-Casa, A. Fernández-Cruz, E. J. de la Rosa# and R. Fernández-Durango# (#, contributing equally) (2008).
Mol Vis 14:1513-1516. - Proinsulin attenuates the loss of vision and delays apoptosis of photoreceptors in a mouse model of retinitis pigmentosa.
S. Corrochano, R. Barhoum, P. Boya, A. I. Arroba, N. Rodríguez-Muela, V. Gómez-Vicente, F. Bosch, F. de Pablo, P. de la Villa and E. J. de la Rosa (2008).
Invest Invest Ophthalmol Vis Sci 49, 4188-4194.
Research Groups
People