Based in King’s College London’s Department of Twin Research and Genetic Epidemiology, the group’s research focuses on the genetics of age-related eye diseases (myopia, glaucoma and age-related cataract), using –omics technologies including genome-wide association studies, whole-genome sequencing and epigenetics, and in particular measuring quantitative healthy variation in these traits in 3000-5000 twins.
Quantitative phenotype collection and follow-up (eg cataract assessment (Scheimpflug lens photograph), retinal vascular caliber (retinal photograph)); GWAS, sequencing, etc
Scientific Cooperations
- Cooperation 1:
Prof Caroline Klaver, Prof Cornelia van Duijn and others in the Rotterdam Eye Study: myopia and glaucoma GWAS - Cooperation 2:
Prof David Mackey, Lions Eye Institute, Perth UWA: twin studies - Cooperation 3:
Dr Ananth Viswanathan and Prof Paul Mitchell, WTCCC2/Blue Mountains Eye Study cohort: glaucoma and cataract GWAS - Cooperation 4:
Prof Jugnoo Rahi, ICH, UCL: myopia genetics - Cooperation 5:
Prof Joan Bailey-Wilson, NIH: myopia GWAS - Cooperation 6:
Dr Fion Bremner, UCLH: pupils - Cooperation 7:
Dr Jelle Vehof, UMCG: dry eye - Cooperation 8:
Prof Terri Young, Duke University, USA: myopia genetics - Cooperation 9:
Prof Barbara and Ron Klein, Beaver Dam (Wisconsin): complex trait gen. epidemiology
Current Research Projects
- Project 1:
The genetics of common age-related eye disease: NIHR Senior Research Fellowship - Project 2:
Rare variants in glaucoma: a whole-genome sequencing study - Project 3:
Cognitive, behavioural, environmental and genetic associations of myopia in the Twins Early Development Study - Project 4:
Identification of genetic susceptibility factors for glaucoma through analysis of large scale genotype and sequencing data - Project 5:
Developing electroretinogram (ERG) protocols to aid early diagnosis of age-related macular degeneration and to understand abnormal retinal function in genetic retinal diseases
Research Groups
People