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Knut Stieger

Short CV

2011 Habilitation in molecular Ophthalmology, Privatdozent
Since 2009 Head of Research group Retinal Gene Therapy, Laboratory of Molecular Ophthalmology, JLU Giessen
2007 – 2009 Postdoctoral Research Fellow, Laboratory of Molecular Ophthalmology, JLU Giessen
2007 PhD in Molecular Biology, University of Nantes, France
2003 – 2007 Graduate Student, The Gene Therapy Laboratory, INSERM U649, University of Nantes, France
2003 Dr. med. vet., University of Leipzig, Germany
1997 – 2003 Studies of Veterinary Medicine, University of Leipzig, Germany


CV of Knut Stieger [pdf]

Scientifc Interest

  • Development of new therapeutic strategies for retinal degenerative and neovascular disorders
  • Characterization of the subcellular and cellular consequences of retinal gene therapy
  • Animal models for retinal disorders
  • Development of highly sensitive diagnostic methods for patients with severe retinal dystrophies


  • ARVO (Association for Research in Vision and Ophthalmology)
  • ASGCT (American Society for Gene and Cell Therapy)
  • DOG (Germany ophthalmological Society)
  • EPOS (European Pediatric Ophthalmological Society)
  • DG-GT (German Society for Gene Therapy)
Knut Stieger
Knut Stieger

Research Group

Retinal Gene Therapy

[more information]


Justus-Liebig-University Giessen

Department of Ophthalmology

Friedrichstrasse 18
35392 Giessen

Phone: +49 641 985-43835
Fax: +49 641 985-43999



Key Publications

  1. Stieger K, Le Meur G, Lasne F, Weber M, Deschamps JY, Nivard D, Mendes-Madeira A, Provost N, Martin L, Moullier P, Rolling F.
    Long-term doxycycline-regulated transgene expression in the retina of nonhuman primates following subretinal injection of recombinant AAV vectors.
    Mol Ther 2006 13:967-975.
  2. Le Meur G, Stieger K, Smith AJ, Weber M, Deschamps JY, Nivard D, Mendes-Madeira A, Provost N, Pereon Y, Cherel Y, Ali RR, Hamel C, Moullier P, Rolling F.
    Restoration of vision in RPE65-deficient Briard dogs using an AAV serotype 4 vector that specifically targets the retinal pigmented epithelium.
    Gene Ther 2007 14:292-303.
  3. Stieger K, Colle MA, Dubreil L, Mendes-Madeira A, Weber M, Le Meur G, Deschamps JY, Provost N, Nivard D, Cherel Y, Moullier P, Rolling F.
    Subretinal delivery of recombinant AAV serotype 8 vector in dogs results in gene transfer to neurons in the brain.
    Mol Ther 2008 16:916-923.
  4. Stieger K, Schroeder J, Provost N, Mendes-Madeira A, Belbellaa B, Meur GL, Weber M, Deschamps JY, Lorenz B, Moullier P, Rolling F.
    Detection of intact rAAV particles up to 6 years after successful gene transfer in the retina of dogs and primates.
    Mol Ther 2009 17:516-523.
  5. Stieger K, Belbelaa B, Le Guiner C, Moullier P, Rolling F.
    In vivo gene regulation using tetracycline regulatable systems.
    Adv Drug Deliv Rev 2009 61(7-8):527-541.
  6. Lheriteau E, Libeau L, Stieger K, Deschamps JY, Mendes-Madeira A, Provost N, Lemoine F, Mellersh C, Ellinwood NM, Cherel Y, Moullier P, Rolling F
    The RPGRIP1-deficient dog, a promising canine model for gene therapy.
    Mol Vis 2009 15:349-361
  7. Lorenz B, Preising M, Stieger K
    Retinal blinding disorders and gene therapy--molecular and clinical aspects.
    Curr Gene Ther 2010 10(5):350-70
  8. Hosch J, Lorenz B, Stieger K
    RPGR: Role in the photoreceptor cilium, human retinal disease, and gene therapy.
    Ophthalmic Genet 2011 32(1):1-11
  9. Lorenz B, Strohmayr E, Zahn S, Friedburg C, Kramer M, Preising M, Stieger K.
    Chromatic pupillometry dissects function of the three different light sensitive retinal cell populations in RPE65 deficiency.
    IOVS 2012 17;53(9):5641-52
  10. Pilch M, Wenner Y, Strohmayr E, Preising M, Friedburg C, Meyer zu Bexten E, Lorenz B, Stieger K.
    Automated segmentation of retinal blood vessels in spectral domain optical coherence tomography scans.
    Biomed Optics Express, 2012 1(7):1478-91

Research Groups