This analysis does not mention the risk of vision loss as a result of untreated cytomegalovirus retinitis in people with HIV, despite the infection's continued prevalence in low-income and middle-income countries. Cytomegalovirus disease was one of three unusual infections in the report by the US Centers for Disease Control and Prevention2 that marked the official start of the AIDS epidemic on June 5, 1981. Before the availability of antiretroviral therapy, cytomegalovirus retinitis, the most common manifestation of AIDS-related cytomegalovirus infection, affected a third of patients with AIDS and accounted for more than 90% of AIDS-related blindness.