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Frank G. Holz

Short CV

1983 - 1989 Medical School, University of Heidelberg, Germany
1988 University of Chicago Pritzker School of Medicine, Chicago, U.S.A. Subinternships in surgery and internal medicine
Former scholar of the German National Scholarship Foundation („Studienstiftung des Deutschen Volkes“)
1992 – 1993 Research and Clinical Fellowship Medical Retina, Institute of Ophthalmology, Moorfields Eye Hospital, London, England, Supervisor: Professor Alan C. Bird, MD, FRCS, FRCOphth
1995 – 2003 „Oberarzt“ at the Department of Ophthalmology, University of Heidelberg, Germany; 2001-2003 „Geschäftsführender Oberarzt“
Since 2003 Chairman and Professor, Department of Ophthalmology, University of Bonn


CV of Frank G. Holz [pdf]

Scientifc Interest

  • Pathogenesis, prognostic factors, biomarkers and treatment of age-related macular degeneration (AMD)
  • Phenotyping retinal diseases by innovative imaging  technologies including confocal scanning laser ophthalmoscopy and spectral domain optical coherence tomography imaging
  • Development and implementation of molecular imaging for macular and retinal diseases
  • Cell biology of  retinal pigment epithelial cells in atrophic and neovascular ocular diseases
  • Clinical trials and innovative therapies for the treatment of macular diseases, especially wet and dry age-related macular degeneration


  • Association for Research in Vision and Ophthalmology (ARVO)
  • American Academy of Ophthalmology
  • Macula Society
  • Club Jules Gonin
  • Deutsche Ophthalmologische Gesellschaft (DOG)
  • Euretina
  • German Retinological Society
  • European Fluorescein-Angiography Club (FAN-Club)
  • Oxford Ophthalmological Congress (OOC)

Further Activities

  • President of the German Society of Ophthalmology (DOG) 2007/2008
  • Member of the Scientific Advisory Board AMD Alliance International
  • Member of the Scientific Advisory Board Pro Retina Germany
  • Editor-in-Chief ‚Der Ophthalmologe’, Springer; Organ of the German Ophthalmological Society (DOG)
  • Editorial board member: Retina, International Ophthalmology, Graefe’s Archive of Clinical and Experimental Ophthalmology, Der Augenspiegel
Frank G. Holz
Frank G. Holz

Research Group

Imaging, pathogenesis and treatment of retinal/macular diseases


University of Bonn, Germany

Department of Ophthalmology
Imaging, pathogenesis and treatment of retinal/macular diseases

Ernst-Abbe-Strasse 2
D-53127 Bonn

Phone: +49 228 287 15647
Fax: +49 228 287 15603



Key Publications

  1. Fleckenstein M, Charbel Issa P, Helb HM, Schmitz-Valckenberg S, Finger RP, Scholl HP, Loeffler KU, Holz FG.
    High-resolution spectral domain-OCT imaging in geographic atrophy associated with age-related macular degeneration.
    Invest Ophthalmol Vis Sci 2008;49:4137-44
  2. Helb HM, Charbel Issa P, van der Veen RL, Berendschot TT, Scholl HP, Holz FG..
    Abnormal macular pigment distribution in type 2 idiopathic macular telangiectasia.
    Retina 2008;28:808-16
  3. Holz FG, Bindewald-Wittich A, Fleckenstein M, Dreyhaupt J, Scholl HP, Schmitz-Valckenberg S;
    FAM-Study Group. Progression of geographic atrophy and impact of fundus autofluorescence patterns in age-related macular degeneration.
    Am J Ophthalmol 2007;143:463-72
  4. F.G. Holz, C. Bellmann, S. Staudt, F. Schütt, H.E. Völcker:
    Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration.
    Investigative Ophthalmology and Visual Science 2001;42:1051-6
  5. M. Bergmann, F. Schütt, F. G. Holz, J. Kopitz:
    Inhibition of the ATP-driven proton pump in RPE lysosomes by the major lipofuscin fluorophor A2-E may contribute to the pathoegnesis of age-related macular degeneration.
    FASEB J 2004;18:562-4
  6. Bindewald-Wittich A, Han M, Schmitz-Valckenberg S, Snyder SR, Giese G, Bille JF, Holz FG.
    Two-Photon–Excited Fluorescence Imaging of Human RPE Cells with a Femtosecond Ti:Sapphire Laser.
    Invest Ophthalmol Vis Sci. 2006;47:4553-57
  7. Scholl HP, Charbel Issa P, Walier M, Janzer S, Pollok-Kopp B, Börncke F, Fritsche LG, Chong NV, Fimmers R, Wienker T, Holz FG, Weber BH, Oppermann M.
    Systemic complement activation in age-related macular degeneration.
    PLoS ONE 2008;3(7):e2593.
  8. F.G. Holz, F. Schütt, J. Kopitz, G.E. Eldred, F.E. Kruse, H.E. Völcker, M. Cantz:
    Inhibition of lysosomal degradative functions in RPE cells by a retinoid component of lipofuscin.
    Investigative Ophthalmology and Visual Science 1999;40:734-7
  9. F.G. Holz, T.J. Wolfensberger, B. Piguet, M. Gross-Jendroska, J.A. Wells, D.C. Minassian, I.H. Chisholm, A.C. Bird:
    Bilateral macular drusen in age-related macular degeneration: Prognosis and Risk Factors.
    Ophthalmology 1994;101:1522-28
  10. F.G. Holz, K. Evans, C.Y. Gregory, S. Bhattacharya, A. C. Bird:
    Autosomal dominant macular dystrophy simulating north carolina macular dystrophy.
    Archives of Ophthalmology 1995;113:178-184

Research Groups