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Thierry Leveillard


Short CV

1989 PhD
Postdoctoral researcher (UCSD, The Salk Institute, IGBMC)
1998 Inserm Chargé de recherche Inserm UMR 592
2006 Inserm Directeur de Recherche Inserm UMR 592 (Institut de la Vision)

Scientifc Interest

Interaction between rods and cones in the perspective of therapeutic approach for retinal diseases

Memberships

  • Association for Research in Vision and Ophthalmology (ARVO)
  • American Society for Gene Therapy

Key Publications

  1. Léveillard T, Sahel JA.
    Rod-derived cone viability factor for treating blinding diseases: from clinic to redox signaling.
    Sci Transl Med. 2010 Apr 7;2(26):26ps16.
  2. Cronin T, Raffelsberger W, Lee-Rivera I, Jaillard C, Niepon ML, Kinzel B, Clérin E, Petrosian A, Picaud S, Poch O, Sahel JA, Léveillard T.
    The disruption of the rod-derived cone viability gene leads to photoreceptor dysfunction and susceptibility to oxidative stress.
    Cell Death Differ. 2010 Feb 5. [Epub ahead of print]
  3. Reichman S, Kalathur RK, Lambard S, Aït-Ali N, Yang Y, Lardenois A, Ripp R, Poch O, Zack DJ, Sahel JA, Léveillard T.
    The homeobox gene CHX10/VSX2 regulates RdCVF promoter activity in the inner retina.
    Hum Mol Genet. 2010 Jan 15;19(2):250-61.
  4. Lambert JC, Heath S, Even G, Campion D, Sleegers K, Hiltunen M, Combarros O, Zelenika D, Bullido MJ, Tavernier B, Letenneur L, Bettens K, Berr C, Pasquier F, Fiévet N, Barberger-Gateau P, Engelborghs S, De Deyn P, Mateo I, Franck A, Helisalmi S, Porcellini E, Hanon O; European Alzheimer's Disease Initiative Investigators, de Pancorbo MM, Lendon C, Dufouil C, Jaillard C, Léveillard T, Alvarez V, Bosco P, Mancuso M, Panza F, Nacmias B, Bossù P, Piccardi P, Annoni G, Seripa D, Galimberti D, Hannequin D, Licastro F, Soininen H, Ritchie K, Blanché H, Dartigues JF, Tzourio C, Gut I, Van Broeckhoven C, Alpérovitch A, Lathrop M, Amouyel P.
    Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.
    Nat Genet. 2009 Oct;41(10):1094-9.
  5. Fridlich R, Delalande F, Jaillard C, Lu J, Poidevin L, Cronin T, Perrocheau L, Millet-Puel G, Niepon ML, Poch O, Holmgren A, Van Dorsselaer A, Sahel JA, Léveillard T.
    The thioredoxin-like protein rod-derived cone viability factor (RdCVFL) interacts with TAU and inhibits its phosphorylation in the retina.
    Mol Cell Proteomics. 2009 Jun;8(6):1206-18.
  6. Yang Y, Mohand-Said S, Danan A, Simonutti M, Fontaine V, Clerin E, Picaud S, Léveillard T, Sahel JA.
    Functional cone rescue by RdCVF protein in a dominant model of retinitis pigmentosa.
    Mol Ther. 2009 May;17(5):787-95.
  7. Kalathur RK, Gagniere N, Berthommier G, Poidevin L, Raffelsberger W, Ripp R, Léveillard T, Poch O.
    RETINOBASE: a web database, data mining and analysis platform for gene expression data on retina.
    BMC Genomics. 2008 May 5;9:208.
  8. Chalmel F, Léveillard T, Jaillard C, Lardenois A, Berdugo N, Morel E, Koehl P, Lambrou G, Holmgren A, Sahel JA, Poch O.
    Rod-derived Cone Viability Factor-2 is a novel bifunctional-thioredoxin-like protein with therapeutic potential.
    BMC Mol Biol. 2007 Aug 31;8:74.
  9. Galy A, Roux MJ, Sahel JA, Léveillard T, Giangrande A.
    Rhodopsin maturation defects induce photoreceptor death by apoptosis: a fly model for RhodopsinPro23His human retinitis pigmentosa.
    Hum Mol Genet. 2005 Sep 1;14(17):2547-57.
  10. Léveillard T, Mohand-Saïd S, Lorentz O, Hicks D, Fintz AC, Clérin E, Simonutti M, Forster V, Cavusoglu N, Chalmel F, Dollé P, Poch O, Lambrou G, Sahel JA.
    Identification and characterization of rod-derived cone viability factor.
    Nat Genet. 2004 Jul;36(7):755-9.
Thierry Leveillard
Thierry Leveillard

Research Group

UMR-S 968

Research Group Thierry Léveillard

Contact

Inserm UMR592

17, rue Moreau
75012 Paris
France

Phone: 33 1 53 46 25 48
Fax-Number: 33 1 53 46 25 02

Email:
thierry.leveillard[at]inserm.fr

Research Groups

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