You are here: vision-research.eu » People » Research Groups » Germany » Seeliger, Mathias

Division of Ocular Neurodegeneration

Our mission is to uncover the pathophysiology of ocular neurodegenerative processes, to develop and test therapeutic strategies, and to understand and model normal retinal function. The basis of our work is in-depth functional and morphological phenotyping of genetic models of blinding human neurodegenerative disorders with electroretinography (ERG), scanning-laser ophthalmoscopy (SLO), and optical coherence tomography (OCT), the same non-invasive techniques used in affected patients.

Methodology

  • Electroretinographic (ERG) techniques
  • Scanning-laser ophthalmoscopy (SLO) in vivo imaging
  • Optic coherence tomography (OCT) in vivo imaging

Scientific Cooperations

  • Cooperation 1:
    Martin Biel, Munich
  • Cooperation 2:
    Pete Humphries, Dublin
  • Cooperation 3:
    Jan Wijnholds, Amsterdam
  • Cooperation 4:
    Christian Grimm, Zurich
  • Cooperation 5:
    Laura Frishman, Houston

Group Leader

Mathias Seeliger
[more information]

Contact

University of Tuebingen
Centre for Ophthalmology
Institute for Ophthalmic Research

Schleichstrasse 4/3
72076 Tuebingen
Germany

Phone: +49-7071-2980718
Fax: +49-7071-294789

Email:
see[at]ieee.org

Website:
www.uak.medizin.uni-tuebingen.de/neurodegen

Current Research Projects

  • Project 1:
    Neurodegeneration research: Investigation of the causes of and the disease mechanisms in retinal degenerations based on animal models with homologous genetic defects to human patients.
  • Project 2:
    Molecular therapy: Development of optimal application procedures and the evaluation of the therapeutic success by short- and long-term follow-up in vivo.
  • Project 3:
    Methodological innovation and refinement:  Development and refinement of innovative diagnostic strategies in human patients and animal models.
  • Project 4:
    Systems biology: Assessment of functional pathways, particularly in the outer retina, by means of mouse lines with specific genetic defects in photoreceptor function and/or connectivity.

Research Groups

People

Related Research Groups

computational modeling
Oops, an error occurred! Code: 20191021002037c92d92ad
electroretinography: clinical
Oops, an error occurred! Code: 201910210020374aab501e
electroretinography: non-clinical
Oops, an error occurred! Code: 20191021002037f9b25314
gene transfer/gene therapy
Oops, an error occurred! Code: 201910210020370e4031a2
imaging/image analysis: non-clinical
Oops, an error occurred! Code: 201910210020378f013501
imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound)
Oops, an error occurred! Code: 2019102100203711274964
imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound)
Oops, an error occurred! Code: 2019102100203785ad028c
retinal connections, networks, circuitry
Oops, an error occurred! Code: 20191021002037492ccf8c
retinal degenerations: cell biology
Oops, an error occurred! Code: 20191021002037173aa404
retinal degenerations: hereditary
Oops, an error occurred! Code: 20191021002037658bc3ed
retinitis pigmentosa
Oops, an error occurred! Code: 20191021002037408fd610
retinoids/retinoid binding proteins
Oops, an error occurred! Code: 20191021002037456a1e37
vitamin A deficiency
Oops, an error occurred! Code: 20191021002037495a3884
hereditary retinal degenerations
Oops, an error occurred! Code: 20191021002037dc2652e4
Animal models
Oops, an error occurred! Code: 201910210020371b71768c
Retinal physiology
Oops, an error occurred! Code: 20191021002037f2a0fe91
Molecular therapy
Oops, an error occurred! Code: 201910210020370d5043c5
Systems biology
Oops, an error occurred! Code: 20191021002037d0cfa36a