vision-research.eu - The Gateway to European Vision Research

Blanca Arango-Gonzalez

Current Research Projects

My current research focuses on neuroprotective strategies employing rat models for Retinitis Pigmentosa (P23H-1 and S334ter-3). Testing of trophic factors, cytokines and enzyme inhibitors on organotypic culture models of degenerating retina will provide us an approach to:

use neuroprotection to prevent or delay photoreceptor cell death;
study signalling pathways that govern live and death of photoreceptors and
proof principles for treatment and to study disease/rescue mechanisms.

Methodology

Organotypic rat retina cultures treated with a range of trophic factors, cytokines and enzyme inhibitors are evaluated using in situ enzyme activity assays, immunostaining, western blot and viability assays.

Selected Publications

Arango-Gonzalez B, Cellerino A, Kohler K
Exogenous brain-derived neurotrophic factor (BDNF) reverts phenotypic changes in the retina of transgenic mice lacking the bdnf gene
IOVS. Accepted
Sancho-Pelluz J, Arango-Gonzalez B, Kustermann S, Romero FJ, van Veen T, Zrenner E, Ekström P, Paquet-Durand F.
Photoreceptor Cell Death Mechanisms in Inherited Retinal Degeneration
Molecular Neurobiology. Accepted
Witkovsky P, Arango-González B, Haycock J, Kohler K.
Rat retinal dopaminergic neurons: differential maturation of somatodendritic and axonal compartments
Journal of Comparative Neurology 481:352-62. (2005)
Pinzón-Duarte G, Arango-González B, Kohler K, Guenther E.
Effects of brain-derived neurotrophic factor on cell survival, differentiation and patterning of neuronal connections and Müller glia cells in the developing retina
European Journal of Neuroscience 19: 1475-1484. (2004)
Cellerino A1, Arango-González B1, Pinzón-Duarte G, Kohler K.
Brain-derived neurotrophic factor regulates expression of vasoactive intestinal polypeptide in retinal amacrine cells
Journal of Comparative Neurology 467:97-104. [1, co-first authors]. (2003)
Pinzón-Duarte G, Kohler K, Arango-González B, Guenther E.
Cell differentiation, synaptogenesis, and influence of the retinal pigment epithelium in a rat neonatal organotypic retina culture
Vision Research 40:3455-3465. (2000)
Cellerino A, Arango-González B and Kohler K.
Effects of brain-derived neurotrophic factor on the development of NADPH-diaphorase/nitric oxide synthase-positive amacrine cells in the rodent retina.
European Journal of Neuroscience 11:2824-2834. (1999)

: Blanca Arango-Gonzalez

Research Group

Division of Experimental Ophthalmology

Contact

University of Tuebingen
Institute for Ophthalmic Research

Roentgenweg 11
72076 Tuebingen
Germany

Phone: +49 (0) 7071 2980741
Fax: +49 (0) 7071 29 5777

Email:
blanca.arango-gonzalez[at]klinikum.uni-tuebingen.de

Documents

CV of Blanca Arango-Gonzalez [pdf]

Research Groups

People

Related Research Groups

apoptosis/cell death: Berendschot, Tos; Cordeiro, M Francesca; Cotter, Tom G.; Cottet, Sandra; De la Rosa, Enrique; Ekström, Per; Griciuc, Ana; Hauck, Stefanie; Heiduschka, Peter; Humphries, Peter; Joachim, Stephanie; Kustermann, Stefan; Marigo, Valeria; Martin, Keith; Miranda Sanz, María; Reinhard, Thomas; Romero, Francisco Javier; Sancho-Pelluz, Javier; Ueffing, Marius; van Veen, Theo
enzymes/enzyme inhibitors: Ekström, Per; Grau, Tanja
growth factors/growth factor receptors: Bovolenta, Paola; Chadderton, Naomi; Cordeiro, M Francesca; De la Rosa, Enrique; Griciuc, Ana; Grimm, Christian; Hicks, David; Krishnakumar, Arjun; Lütjen-Drecoll, Elke; Strauss, Olaf; Ueffing, Marius; van Veen, Theo
neuroprotection: Andrés-Guerrero, Vanessa; Auricchio, Alberto; Chadderton, Naomi; Cordeiro, M Francesca; Cottet, Sandra; Ekström, Per; Enzmann, Volker; Grimm, Christian; Hauck, Stefanie; Heiduschka, Peter; Hicks, David; Humphries, Peter; Joachim, Stephanie; Karl, Mike O.; Kremers, Jan; Kustermann, Stefan; Lagreze, Wolf; Martin, Keith; Miranda Sanz, María; Paquet-Durand, Francois; Sennlaub, Florian; Tsilimbaris, Miltiadis; Romero, Francisco Javier; Sahaboglu, Ayse; Sancho-Pelluz, Javier; Scanlon, Peter; Skorkovská, Karolína; Ueffing, Marius; van Veen, Theo; Zrenner, Eberhart
opsins: Cottet, Sandra; Grau, Tanja; Griciuc, Ana
photoreceptors: Ader, Marius; Arden, Geoffrey; Artal, Pablo; Auricchio, Alberto; Baraas, Rigmor; Berendschot, Tos; Berger, Wolfgang; Biel, Martin; Bovolenta, Paola; Bujakowska, Kinga; Cangiano, Lorenzo; Chadderton, Naomi; Cottet, Sandra; Ekström, Per; Goureau, Olivier; Heiduschka, Peter; Hicks, David; Julien, Sylvie; Kamermans, Maarten; Kawasaki, Aki; Kennedy, Breandan; Kremers, Jan; Langmann, Thomas; Larsen, Michael; MacLaren, Robert; Marigo, Valeria; Michalakis, Stylianos; O'Driscoll, Ciara; Palfi, Arpad; Paquet-Durand, Francois; Sennlaub, Florian; Tsilimbaris, Miltiadis; Vignali, Roberto; Roska, Botond; Sahaboglu, Ayse; Sancho-Pelluz, Javier; Strettoi, Enrica; Ueffing, Marius; van Veen, Theo; Wijnholds, Jan; Wissinger, Bernd; Wolfrum, Uwe; Zeitz, Christina
retinal culture: Ader, Marius; Ekström, Per; Goureau, Olivier; Kustermann, Stefan; Langmann, Thomas; Martin, Keith; Paquet-Durand, Francois; Pastor, Jose-Carlos; Picaud, Serge; Reichenbach, Andreas; Sennlaub, Florian; Tsilimbaris, Miltiadis; Sahaboglu, Ayse; Sancho-Pelluz, Javier; Thanos, Solon; van Veen, Theo; Wolfrum, Uwe
retinal degenerations: cell biology: Arden, Geoffrey; Audo, Isabelle; Bhattacharya, Shomi; Biel, Martin; Bird, Alan; Bovolenta, Paola; Bujakowska, Kinga; Cordeiro, M Francesca; Ekström, Per; Enzmann, Volker; Greenwood, John; Grimm, Christian; Hauck, Stefanie; Heiduschka, Peter; Hicks, David; Johnsen-Soriano, Siv; Karl, Mike O.; Kennedy, Breandan; Kustermann, Stefan; Langmann, Thomas; Lengyel, Imre; Marigo, Valeria; Martin, Keith; Michalakis, Stylianos; Palfi, Arpad; Paquet-Durand, Francois; Picaud, Serge; Reichenbach, Andreas; Stitt, Alan; Sennlaub, Florian; Tsilimbaris, Miltiadis; Roepman, Ronald; Sancho-Pelluz, Javier; Seeliger, Mathias; Stieger, Knut; Strauss, Olaf; Strettoi, Enrica; Sørensen, Torben Lykke; Thanos, Solon; Ueffing, Marius; Weber, Bernhard; Wijnholds, Jan; Wolfrum, Uwe
retinal development: Ader, Marius; Banfi, Sandro; Bovolenta, Paola; Goureau, Olivier; Hindges, Robert; Karl, Mike O.; Moore, Tony; Reichenbach, Andreas; Tsilimbaris, Miltiadis; Vignali, Roberto; Thanos, Solon; van Heyningen, Veronica
retinitis pigmentosa: Ader, Marius; Audo, Isabelle; Auricchio, Alberto; Bach, Michael; Bergen, Arthur; Berger, Wolfgang; Bhattacharya, Shomi; Biel, Martin; Bird, Alan; Bovolenta, Paola; Bujakowska, Kinga; Chadderton, Naomi; Cremers, Frans; De la Rosa, Enrique; den Hollander, Anneke; Dollfus, Hélène; Enzmann, Volker; Fighting Blindness; Griciuc, Ana; Hamel, Christian; Langmann, Thomas; Larsen, Michael; MacLaren, Robert; Michalakis, Stylianos; Moore, Tony; Palfi, Arpad; Paquet-Durand, Francois; Tsilimbaris, Miltiadis; Rivolta, Carlo; Romero, Francisco Javier; Sahaboglu, Ayse; Sancho-Pelluz, Javier; Seeliger, Mathias; van Veen, Theo; Wijnholds, Jan; Wolfrum, Uwe; Wright, Alan; Zrenner, Eberhart

Missing some information on vision-research.eu?

* mandatory field