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Blanca Arango-Gonzalez

Current Research Projects

My current research focuses on neuroprotective strategies employing rat models for Retinitis Pigmentosa (P23H-1 and S334ter-3). Testing of trophic factors, cytokines and enzyme inhibitors on organotypic culture models of degenerating retina will provide us an approach to:

  1. use neuroprotection to prevent or delay photoreceptor cell death;
  2. study signalling pathways that govern live and death of photoreceptors and
  3. proof principles for treatment and to study disease/rescue mechanisms.

Methodology

Organotypic rat retina cultures treated with a range of trophic factors, cytokines and enzyme inhibitors are evaluated using in situ enzyme activity assays, immunostaining, western blot and viability assays.

Selected Publications

  1. Arango-Gonzalez B, Cellerino A, Kohler K
    Exogenous brain-derived neurotrophic factor (BDNF) reverts phenotypic changes in the retina of transgenic mice lacking the bdnf gene
    IOVS. Accepted
  2. Sancho-Pelluz J, Arango-Gonzalez B, Kustermann S, Romero FJ, van Veen T, Zrenner E, Ekström P, Paquet-Durand F.
    Photoreceptor Cell Death Mechanisms in Inherited Retinal Degeneration
    Molecular Neurobiology. Accepted
  3. Witkovsky P, Arango-González B, Haycock J, Kohler K.
    Rat retinal dopaminergic neurons: differential maturation of somatodendritic and axonal compartments
    Journal of Comparative Neurology 481:352-62. (2005)
  4. Pinzón-Duarte G, Arango-González B, Kohler K, Guenther E.
    Effects of brain-derived neurotrophic factor on cell survival, differentiation and patterning of neuronal connections and Müller glia cells in the developing retina
    European Journal of Neuroscience 19: 1475-1484. (2004)
  5. Cellerino A1, Arango-González B1, Pinzón-Duarte G, Kohler K.
    Brain-derived neurotrophic factor regulates expression of vasoactive intestinal polypeptide in retinal amacrine cells
    Journal of Comparative Neurology 467:97-104. [1, co-first authors]. (2003)
  6. Pinzón-Duarte G, Kohler K, Arango-González B, Guenther E.
    Cell differentiation, synaptogenesis, and influence of the retinal pigment epithelium in a rat neonatal organotypic retina culture
    Vision Research 40:3455-3465. (2000)
  7. Cellerino A, Arango-González B and Kohler K.
    Effects of brain-derived neurotrophic factor on the development of NADPH-diaphorase/nitric oxide synthase-positive amacrine cells in the rodent retina.
    European Journal of Neuroscience 11:2824-2834. (1999)
Blanca Arango-Gonzalez
Blanca Arango-Gonzalez

Research Group

Division of Experimental Ophthalmology

Contact

University of Tuebingen
Institute for Ophthalmic Research

Roentgenweg 11
72076 Tuebingen
Germany

Phone: +49 (0) 7071 2980741
Fax: +49 (0) 7071 29 5777

Email:
blanca.arango-gonzalez[at]klinikum.uni-tuebingen.de

Research Groups

People

Related Research Groups

apoptosis/cell death
Berendschot, Tos
Cordeiro, M Francesca
Cotter, Tom G.
Cottet, Sandra
De la Rosa, Enrique
Ekström, Per
Griciuc, Ana
Hauck, Stefanie
Heiduschka, Peter
Humphries, Peter
Joachim, Stephanie
Kustermann, Stefan
Marigo, Valeria
Martin, Keith
Miranda Sanz, María
Reinhard, Thomas
Romero, Francisco Javier
Sancho-Pelluz, Javier
Ueffing, Marius
van Veen, Theo
enzymes/enzyme inhibitors
Ekström, Per
Grau, Tanja
growth factors/growth factor receptors
Bovolenta, Paola
Chadderton, Naomi
Cordeiro, M Francesca
De la Rosa, Enrique
Griciuc, Ana
Grimm, Christian
Hicks, David
Krishnakumar, Arjun
Lütjen-Drecoll, Elke
Strauss, Olaf
Ueffing, Marius
van Veen, Theo
neuroprotection
Andrés-Guerrero, Vanessa
Auricchio, Alberto
Chadderton, Naomi
Cordeiro, M Francesca
Cottet, Sandra
Ekström, Per
Enzmann, Volker
Grimm, Christian
Grus, Franz
Hauck, Stefanie
Heiduschka, Peter
Hicks, David
Humphries, Peter
Joachim, Stephanie
Karl, Mike O.
Kremers, Jan
Kustermann, Stefan
Lagreze, Wolf
Martin, Keith
Miranda Sanz, María
Paquet-Durand, Francois
Sennlaub, Florian
Tsilimbaris, Miltiadis
Romero, Francisco Javier
Sahaboglu, Ayse
Sancho-Pelluz, Javier
Scanlon, Peter
Skorkovská, Karolína
Ueffing, Marius
van Veen, Theo
Zrenner, Eberhart
opsins
Cottet, Sandra
Dell'Orco, Daniele
Grau, Tanja
Griciuc, Ana
photoreceptors
Ader, Marius
Arden, Geoffrey
Artal, Pablo
Auricchio, Alberto
Baraas, Rigmor
Berendschot, Tos
Berger, Wolfgang
Biel, Martin
Bovolenta, Paola
Bujakowska, Kinga
Cangiano, Lorenzo
Chadderton, Naomi
Cottet, Sandra
Dell'Orco, Daniele
Ekström, Per
Goureau, Olivier
Heiduschka, Peter
Hicks, David
Julien, Sylvie
Kamermans, Maarten
Kawasaki, Aki
Kennedy, Breandan
Kremers, Jan
Langmann, Thomas
Larsen, Michael
MacLaren, Robert
Marigo, Valeria
O'Driscoll, Ciara
Palfi, Arpad
Paquet-Durand, Francois
Sennlaub, Florian
Tsilimbaris, Miltiadis
Vignali, Roberto
Roska, Botond
Sahaboglu, Ayse
Sancho-Pelluz, Javier
Strettoi, Enrica
Ueffing, Marius
van Veen, Theo
Wijnholds, Jan
Wissinger, Bernd
Wolfrum, Uwe
Zeitz, Christina
retinal culture
Ader, Marius
Ekström, Per
Goureau, Olivier
Grus, Franz
Kustermann, Stefan
Langmann, Thomas
Martin, Keith
Paquet-Durand, Francois
Pastor, Jose-Carlos
Picaud, Serge
Reichenbach, Andreas
Sennlaub, Florian
Tsilimbaris, Miltiadis
Sahaboglu, Ayse
Sancho-Pelluz, Javier
Thanos, Solon
van Veen, Theo
Wolfrum, Uwe
retinal degenerations: cell biology
Arden, Geoffrey
Audo, Isabelle
Bhattacharya, Shomi
Biel, Martin
Bird, Alan
Bovolenta, Paola
Bujakowska, Kinga
Cordeiro, M Francesca
Ekström, Per
Enzmann, Volker
Greenwood, John
Grimm, Christian
Hauck, Stefanie
Heiduschka, Peter
Hicks, David
Johnsen-Soriano, Siv
Karl, Mike O.
Kennedy, Breandan
Kustermann, Stefan
Langmann, Thomas
Lengyel, Imre
Marigo, Valeria
Martin, Keith
Palfi, Arpad
Paquet-Durand, Francois
Picaud, Serge
Reichenbach, Andreas
Stitt, Alan
Sennlaub, Florian
Tsilimbaris, Miltiadis
Roepman, Ronald
Sancho-Pelluz, Javier
Seeliger, Mathias
Stieger, Knut
Strauss, Olaf
Strettoi, Enrica
Sørensen, Torben Lykke
Thanos, Solon
Ueffing, Marius
Weber, Bernhard
Wijnholds, Jan
Wolfrum, Uwe
retinal development
Ader, Marius
Banfi, Sandro
Bovolenta, Paola
Goureau, Olivier
Hindges, Robert
Karl, Mike O.
Moore, Tony
Reichenbach, Andreas
Tsilimbaris, Miltiadis
Vignali, Roberto
Thanos, Solon
van Heyningen, Veronica
retinitis pigmentosa
Ader, Marius
Audo, Isabelle
Auricchio, Alberto
Bach, Michael
Bergen, Arthur
Berger, Wolfgang
Bhattacharya, Shomi
Biel, Martin
Bird, Alan
Bovolenta, Paola
Bujakowska, Kinga
Chadderton, Naomi
Cremers, Frans
De la Rosa, Enrique
den Hollander, Anneke
Dollfus, Hélène
Enzmann, Volker
Fighting Blindness
Griciuc, Ana
Hamel, Christian ✝
Langmann, Thomas
Larsen, Michael
MacLaren, Robert
Moore, Tony
Palfi, Arpad
Paquet-Durand, Francois
Tsilimbaris, Miltiadis
Rivolta, Carlo
Romero, Francisco Javier
Sahaboglu, Ayse
Sancho-Pelluz, Javier
Seeliger, Mathias
van Veen, Theo
Wijnholds, Jan
Wolfrum, Uwe
Wright, Alan
Zrenner, Eberhart

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