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Blanca Arango-Gonzalez

Current Research Projects

My current research focuses on neuroprotective strategies employing rat models for Retinitis Pigmentosa (P23H-1 and S334ter-3). Testing of trophic factors, cytokines and enzyme inhibitors on organotypic culture models of degenerating retina will provide us an approach to:

  1. use neuroprotection to prevent or delay photoreceptor cell death;
  2. study signalling pathways that govern live and death of photoreceptors and
  3. proof principles for treatment and to study disease/rescue mechanisms.

Methodology

Organotypic rat retina cultures treated with a range of trophic factors, cytokines and enzyme inhibitors are evaluated using in situ enzyme activity assays, immunostaining, western blot and viability assays.

Selected Publications

  1. Arango-Gonzalez B, Cellerino A, Kohler K
    Exogenous brain-derived neurotrophic factor (BDNF) reverts phenotypic changes in the retina of transgenic mice lacking the bdnf gene
    IOVS. Accepted
  2. Sancho-Pelluz J, Arango-Gonzalez B, Kustermann S, Romero FJ, van Veen T, Zrenner E, Ekström P, Paquet-Durand F.
    Photoreceptor Cell Death Mechanisms in Inherited Retinal Degeneration
    Molecular Neurobiology. Accepted
  3. Witkovsky P, Arango-González B, Haycock J, Kohler K.
    Rat retinal dopaminergic neurons: differential maturation of somatodendritic and axonal compartments
    Journal of Comparative Neurology 481:352-62. (2005)
  4. Pinzón-Duarte G, Arango-González B, Kohler K, Guenther E.
    Effects of brain-derived neurotrophic factor on cell survival, differentiation and patterning of neuronal connections and Müller glia cells in the developing retina
    European Journal of Neuroscience 19: 1475-1484. (2004)
  5. Cellerino A1, Arango-González B1, Pinzón-Duarte G, Kohler K.
    Brain-derived neurotrophic factor regulates expression of vasoactive intestinal polypeptide in retinal amacrine cells
    Journal of Comparative Neurology 467:97-104. [1, co-first authors]. (2003)
  6. Pinzón-Duarte G, Kohler K, Arango-González B, Guenther E.
    Cell differentiation, synaptogenesis, and influence of the retinal pigment epithelium in a rat neonatal organotypic retina culture
    Vision Research 40:3455-3465. (2000)
  7. Cellerino A, Arango-González B and Kohler K.
    Effects of brain-derived neurotrophic factor on the development of NADPH-diaphorase/nitric oxide synthase-positive amacrine cells in the rodent retina.
    European Journal of Neuroscience 11:2824-2834. (1999)
Blanca Arango-Gonzalez
Blanca Arango-Gonzalez

Research Group

Division of Experimental Ophthalmology

Contact

University of Tuebingen
Institute for Ophthalmic Research

Roentgenweg 11
72076 Tuebingen
Germany

Phone: +49 (0) 7071 2980741
Fax: +49 (0) 7071 29 5777

Email:
blanca.arango-gonzalez[at]klinikum.uni-tuebingen.de

Research Groups

People

Related Research Groups

apoptosis/cell death
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enzymes/enzyme inhibitors
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growth factors/growth factor receptors
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neuroprotection
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opsins
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photoreceptors
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retinal culture
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retinal degenerations: cell biology
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retinal development
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retinitis pigmentosa
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