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Alberto Auricchio

Short CV

  • Alberto Auricchio, MD is Associate Professor of Medical Genetics at the “Federico II” University in Naples and Full Investigator at the Telethon Institute of Genetics and Medicine in Naples.
  • Dr. Auricchio’s research is focused on gene therapy of retinal and metabolic diseases using adeno-associated viral vectors.
  • Dr. Auricchio is co-author of more than 60 peer-reviewed publications on international scientific journals.
  • Dr. Auricchio is inventor on several international patents on the use of viral vectors for gene therapy.
  • Dr. Auricchio is a member of the Editorial boards of Human Gene Therapy and Molecular Therapy.
  • Dr. Auricchio received the 2006 Outstanding New Investigator Award of the American Society of Gene Therapy
  • Dr. Auricchio has been nominated in 2007 "Cavaliere of the Italian Republic" by the President of the Italian Republic.

Scientifc Interest

  • Development and application of viral vectors for retinal gene transfer for retinal degeneration and neovascularization.
  • Translational research for gene therapy of inherited retinaldegenerations (Leber’s congenital amaurosis, Stargardt’s disease, retinitis pigmentosa)

Further Activities

  • Gene therapy mediated by adenoassociated viral vectors for treatment of Lysosomal Storage Disorders

Memberships

  • American Society of Gene Therapy (ASGT)
  • Association for Research in Vision and Ophthalmology (ARVO)
  • European Society of Gene Therapy (ESGT)
  • New York Academy of Sciences: 2004-2005
Alberto Auricchio
Alberto Auricchio

Research Group

Telethon Institute Of Genetics And Medicine (TIGEM)

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Contact

Telethon Institute Of Genetics And Medicine

Via Pietro Castellino, 111
80131 Naples
Italy

Phone: 0039-081-6132229
Fax: 0039-081-5790919

Email:
auricchio[at]tigem.it

Website:
www.tigem.it

Key Publications

  1. F. Simonelli, A.M. Maguire, F. Testa, E.A. Pierce, F. Mingozzi, J.L. Bennicelli, S. Rossi, K. Marshall, S. Banfi, E.M. Surace, J. Sun, T.M. Redmond, X. Zhu, K.S. Scindler, G.S. Ying, C. Ziviello, C. Acerra, J.F. Wright, J.W. McDonnell, K.A. High, J. Bennett, A.Auricchio (2009)
    Gene Therapy for Leber's Congenital Amaurosis is Safe and Effective Through 1.5 Years After Vector Administration.
    Mol. Ther. 18(3):643-50. PMID: 19953080.
  2. A.M. Maguire, K.A. High, A. Auricchio, J.F. Wright, E.A. Pierce, F. Testa, F. Mingozzi, J.L. Bennicelli, G.S. Ying, S. Rossi, A. Fulton, K.A. Marshall, S. Banfi, D.C. Chung, J.I. Morgan, B. Hauck, O. Zelenaia, X. Zhu, L. Raffini, F. Coppieters, E. De Baere, K.S. Shindler, N.J. Volpe, E.M. Surace, C. Acerra, A. Lyubarsky, T.M. Redmend, E. Stone, J. Sun, J.W. McDonnell, B.P. Leroy, F. Simonelli, J. Bennett (2009)
    Age-dependent effects of RPE65 gene therapy for Leber’s congenital amaurosis: a phase 1 dose escalation trial.
    Lancet. 7;374(9701):1597-605. PMID: 19854499.
  3. A. Bello, K. Tran, M. Doria, M. Allocca, M. Hildinger, D. Beniac, C. Kranendonk, A. Auricchio, G. P. Kobinger (2009)
    Isolation and evaluation of novel adeno-associated virus sequences from porcine tissues.
    Gene Therapy advance online publication 23 July 2009. PMID: 19626054.
  4. P. Colella, G. Cotugno, A. Auricchio (2009)
    Ocular gene therapy:current progress and future prospects. Trends in Molecular Medicine. 15(1):23-31. PMID: 19097940 IF 9.621
  5. A. M. Maguire, F. Simonelli, E. A. Pierce, E. N. Jr Pugh, F. Mingozzi, J. Bennicelli, S. Banfi, K. A. Marshall , F. Testa , E. M. Surace, S. Rossi, A. Lyubarsky, V.R. Arruda, B. Konkle, E. Stone, J. Sun, J. Jacobs, L. Dell'Osso, R. Hertle, J. X. Ma, T. M. Redmond, X. Zhu, B. Hauck, O. Zelenaia, K. S. Shindler, M. G. Maguire, J. F. Wright, N. J. Volpe, J. W. McDonnell, A. Auricchio *, K.A. High *, J. Bennett* (2008)
    Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis.
    N Engl J Med. 358(21):2240-8. *co-corresponding authors. PMID: 18441370
  6. M. Allocca, M. Doria, M. Petrillo, M. P. Colella, G. Hoyos, D. Gibbs , S. R. Kim, A. Maguire, T. S. Rex, U. Di Vicino, L. Cutillo, J. R. Sparrow, D. S.Wiliams, J. Bennett and A. Auricchio (2008)
    Serotype-dependent packaging of large genes in adeno-associated viral vectors results in effective in vivo gene delivery.
    J. Clin. Invest. 118(5):1955-64. PMID: 18414684
  7. M. Allocca, U. Di Vicino, M. Petrillo, F. Carlomagno, L. Domenici, A. Auricchio (2007)
    Constitutive and AP20187-induced ret activation in photoreceptors does not protect from light-induced damage.
    IOVS. 48(11):5199-206. PMID:17962474
  8. M. Allocca, C. Mussolino, M. Garcia-Hoyos, D. Sanges, C. Iodice, M. Petrillo, L. H. Vandenberghe, J. M. Wilson, V. Marigo, E. M. Surace, A. Auricchio (2007)
    Novel adeno-associated virus serotypes efficiently transduce murinephotoreceptors.
    J Virol. 81(20):11372-80. PMID: 17699581.
  9. Tessitore, F. Parisi, M. A. Denti, M. Allocca, U. Di Vicino, L. Domenici, I. Bozzoni, A. Auricchio (2006)
    Preferential silencing of a common dominant rhodopsin mutation does not inhibit retinal degeneration in a transgenic model.
    Mol. Ther. 14(5):692-9. PMID:16979943
  10. E. M. Surace, K. S. Balaggan, A. Tessitore, C. Mussolino, G. Cotugno, C. Bonetti, A. Vitale, R. R. Ali, A. Auricchio (2006)
    Inhibition of ocular neovascularization by Hedgehog blockade.
    Mol. Ther. 13(3):573-9. PMID: 16343995.

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