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Deniz Dalkara

Current Research Projects

Engineering Adeno-associated viral vectors for targeting specific subsets of cells in the retina and using these AAV varients for therapeutic gene delivery in the context of retinal degenerations

Methodology

  • Directed evolution of AAV capsids, qPCR, rAAV production
  • Intraoular injections in rodents (rats, mice)
  • Flow cytometry, immunohistochemistry, electroretinography (ERGs)

Selected Publications

  1. Dalkara D. / Kolstad KD, Guerin K, Visel M, Hoffmann N, Schaffer DV, Flannery JG
    Changes in adeno-associated virus-mediated gene delivery in retinal degeneration.
    Human Gene Therapy, 2010 May;21(5):571-8.
  2. Klimczak RR, Koerber JT, Dalkara D, Flannery JG, Schaffer DV.
    A novel adeno-associated viral variant for efficient and selective intravitreal transduction of rat Müller cells.
    PLoS One., 2009 Oct 14;4(10):e7467.
  3. Dalkara D, Kolstad KD, Caporale N, Visel M, Klimczak RR, Schaffer DV, Flannery JG.
    Inner limiting membrane barriers to AAV-mediated retinal transduction from the vitreous.
    Molecular Therapy, 2009 Dec;17(12):2096-102. Epub 2009 Aug 11.
  4. Koerber JT, Klimczak R, Jang JH, Dalkara D, Flannery JG, Schaffer DV.
    Molecular evolution of adeno-associated virus for enhanced glial gene delivery.
    Molecular Therapy, 2009 Dec;17(12):2088-95. Epub 2009 Aug 11.
  5. Courtête J, Sibler AP, Zeder-Lutz G, Dalkara D, Oulad-Abdelghani M, Zuber G, Weiss E.
    Suppression of cervical carcinoma cell growth by intracytoplasmic codelivery of anti-oncoprotein E6 antibody and small interfering RNA.
    Mol Cancer Ther., 2007 Jun;6(6):1728-35.
Deniz Dalkara
Deniz Dalkara

Research Group

The Flannery laboratory

Contact

University of California

112 Barker Hall
Berkeley, CA 94720
USA

Phone: (510) 642-0209

Email:
deniz.dalkara[at]gmail.com

Website:
http://mcb.berkeley.edu/labs/flannery/

Documents

CV of Deniz Dalkara [pdf]

Research Groups

People

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