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Tear film, ocular surface and dry eye

Our group is mainly interested in the function of proteins and peptides that influence tear film peptides (beta defensins, proriasin, and other), surfactant proteins and also hormones such as somatostatin or relaxin.

Moreover, we try to understand physiologic and pathophysiolic mechanisms of cornea, conjunctiva, lacrimal gland, accessory lacrimal glands, Meibomian glands, lid margin, lids, and nasolacrimal ducts. Finally, major focus is on lacrimal gland reconstruction and lacrimal gland stem cell research.

Methodology

  • Cell culture,
  • cell lines (cornea, conjunctiva, meibocytes),
  • dry eye model (mice),
  • cornea wound healing models,
  • immunogold electron microscopy,
  • cell biology,
  • molecular biology

Group Leader

Friedrich Paulsen
[more information]

Contact

Friedrich-Alexander-University Erlangen-Nuremberg

Department of Anatomy II

Universitätsstr. 19
91054 Erlangen
Germany

Phone: +49 91318522865
Fax: +49 91318522862

E-mail:
friedrich.paulsen[at]anatomie2.med.uni-erlangen.de

Website:
www.anatomie2.med.uni-erlangen.de

Scientific Cooperations

  • Cooperation 1
    Yolanda Diebold, IOBA, Valladolid, Spain
  • Cooperation 2
    Thomas Millar, School of Natural Sciences, University of Sydney, Australia
  • Cooperation 3
    Robert Sack, College of Opthometry, SUNY, NY, USA
  • Cooperation 4
    Monica Berry, School of Clinical Sciences, University of Bristol, UK
  • Cooperation 5
    Stephan Mergler, Group leader ophthalmology research lab, Charité, Berlin, Germany

Current Research Projects

  • Project 1
    Detection and function of antimicrobial peptides in the tear film
  • Project 2
    Proteins of meibomian glands
  • Project 3
    Regulation of meibomian gland secretion
  • Project 4
    Stem cells of lacrimal gland
  • Project 5
    Function of surfactant proteins in the tear film

Research Groups

People

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