You are here: vision-research.eu » Vision Research » Vacancies

07/20/18

PhD position: Calcium channels in congenital stationary night blindness

Photoreceptors are morphologically and physiological highly specialised light sensing cells of the retina where sustained release of glutamate from ribbon synapses is calcium dependent and L-type calcium channels (LTCC) serve as the predominant source for Ca2+ entry. Mutations in the CACNA1F gene encoding Cav1.4 LTCCs were identified among patients diagnosed with congenital night blindness type 2 (OMIM: 30071). Ongoing work investigates the important role of Cav1.4 channels as calcium source for neurotransmitter release and stabilizers of the retinal synapse. The aim of this PhD project is to test the pharmaco-therapeutic potential of retinal LTCCs using gene therapy.

Methods: Retinal morphology and synapse structure (high-resolution fluorescent and electron microscopy; dye filling); functional analyses in retinal whole-mounts and slices (patch-clamp, slice electrophysiology; multielectrode array analyses); cell culture; retinal AAV gene-therapy.

References: Knoflach et al. (2015) Channels (Austin) 9(5):298-306; Bacchi et al. (2015) IOVS 56(8):4846-56.; Seitter and Koschak (2018) Neuropharmacology 132:58-70. (Review); Pangrsic et al. (2018) Physiol Reviews (Review).

Salary: According to the rates of the Austrian Science Fund (FWF) for PhD students plus travel funds for international scientific meetings.

Contact: Ao. Univ. Prof. Alexandra Koschak, University of Innsbruck, Institute of Pharmacy, Pharmacology and Toxicology, Innrain 80/82, 6020 Innsbruck, Austria
E-mail: alexandra.koschak[at]uibk.ac.at

Deadline for application: September 10, 2018

More information and application: The successful candidate will be part of the Neuroscience PhD program CavX-Calcium channels in excitable cells:

To top

Further Vacancies

If you have an open position and would like it to be presented on vision-research.eu - please send us the details

Please note: All information provided are supplied without liability!