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Uwe Wolfrum

Short CV

Uwe Wolfrum got his training in Biology at the University of Bayreuth and of Regensburg.

He received his PhD from the University of Regensburg and did Postdocs the Mayo Clinic Foundation, Rochester, MN.

In 1998 he got his habilitation at the University of Karlsruhe.

Since 1999 he is Full Professor for Zoology and Cell Biology at Johannes Gutenberg University of Mainz.

His research interest is in photoreceptor and retina cell biology providing novel insights into the molecular intracellular transport.

With respect to disease, his group investigates molecular basis of the human Usher syndrome (Usher protein interactome) and searches for gene-based therapeutics targeting neurodegeneration in the retina.

Scientifc Interest

  • Sensory cell biology
  • Photoreceptor and retina cell biology
  • Protein networks - interactomes
  • Usher syndrome
  • Molecular genetic strategies of gene based therapy

Further Activities

  • Chairman of the scientific advisory board of “Forschung contra Blindheit – Initiative Usher-Syndom e.V. (FcB)”

Memberships

  • Association for Research in Vision and Ophthalmology (ARVO)
  • American Society for Cell biology (ASCB)
  • European Society for Neuroscience (FENS)
  • German Society for Zoology (DZG)
  • German Society for Cell Biology (DGZ)
  • German Society for Neuroscience
Uwe Wolfrum
Uwe Wolfrum

Research Group

Sensory cell biology
[more information]

Contact

Johannes Gutenberg-University Mainz

Cell und Matrix Biology
Institute of Zoology
Muellerweg
655099 Mainz
Germany

Phone: +49 6131 392-5148
Fax: +49 6131 392-3815

Email:
wolfrum[at]uni-mainz.de

Website:
www.ag-wolfrum.bio.uni-mainz.de

Key Publications

  1. Schneider E, Märker T, Daser A, Frey-Mahn G, Beyer V, Farcas R, Schneider-Rätzke B, Kohlschmidt N, Grossmann B, Bauss K, Napiontek U, Keilmann A, Bartsch O, Zechner U, Wolfrum U, Haaf T (2009)
    Homozygous disruption of PDZD7 by reciprocal translocation in a consanguineous family: a new member of the Usher syndrome protein interactome causing congenital hearing impairment.
    Hum Mol Genet 18:655-666.
  2. Reidel B, Goldmann T, Gießl A, Wolfrum U (2008)
    The translocation of signaling molecules in dark adapting mammalian rod photoreceptor cells is dependent on the cytoskeleton.
    Cell Motil Cytoskeleton 65:785-800
  3. Maerker T, van Wijk E, Overlack N, Kersten FFJ, McGee J, Goldmann T, Sehn E, Roepman R, Walsh EJ, Kremer H, Wolfrum U (2008)
    A novel Usher protein network at the periciliary reloading point between molecular transport machineries in vertebrate photoreceptor cells.
    Hum Mol Genet 17:71-86.
  4. Trojan P, Gießl A, Choe H-W, Krauß N, Pulvermüller A, Wolfrum U (2008)
    Centrin function in vertebrate photoreceptor cells.
    Prog Retin Eye Res 28: 237-259
  5. Trojan P, Rausch S, Gießl A, Klemm C, Krause E, Pulvermüller A, Wolfrum U (2008)
    Light-dependent CKII-mediated phosphorylation regulates complex formation with visual G-protein.
    Biochimica et Biophysica Acta - Mol Cell Res 1783: 1248-1260
  6. den Hollander AI., Koenekoo RK, Mohamed MD, Arts HH, Boldt K, Towns KV, Sedmak T, Beer M, Nagel-Wolfrum K, McKibbin M, Dharmaraj S, Lopez I, Ivings L, Williams GA, Springell K, Woods CG, Jafri H, Rashid Y, Strom TM, van der Zwaag B, Gosens I, Kersten FFJ, van Wijk E, Veltman JA, Zonneveld MN, van Beersum SEC, Maumenee IH, Wolfrum U, Cheetham ME, Ueffing M, Cremers FPM, Inglehearn CF, Roepman R (2007)
    Mutations in LCA5, encoding the ciliary protein lebercilin, cause Leber congenital amaurosis.
    Nat Genet 39:889–895.
  7. Reiners J, Nagel-Wolfrum K, Jürgens K, Märker T, Wolfrum U (2006)
    Molecular basis of human Usher syndrome: deciphering the meshes of the Usher protein network provides insights into the pathomechanisms of the Usher disease.
    Exp Eye Res 83:97
    (10. most downloaded article published in Exp Eye Res)
  8. Reiners J, van Wijk E, Märker T, Zimmermann U, Jürgens K, te Brinke H, Overlack, N, Roepman R, Knipper M, Kremer H, Wolfrum U (2005)
    Scaffold protein harmonin (USH1C) provides molecular links between Usher syndrome type 1 and type 2.
    Hum Mol Genet 14:3933-3943.
  9. Reiners J, Reidel B, El Amraoui A, Boëda B, Huber I, Petit C, Wolfrum U (2003)
    Differential distribution of harmonin isoforms and their possible role in Usher 1 protein complexes in mammalian photoreceptor cells.
    Invest Ophthalmol Visual Sci 44:5006
  10. Tai AW, Chuang J-Z, Bode C, Wolfrum U, Sung C-H (1999)
    Rhodopsin´s carboxy-terminal cytoplasmic tail acts as a membrane receptor for cytoplasmic dynein by binding the dynein light chain Tctex-1.
    Cell 97:877-887.

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