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Thomas Langmann

Short CV

1995 Diploma in Biology
1998 PhD, University of Regensburg, Institute of Clinical Chemistry and Laboratory Medicine, Germany
1999-2000 Post-doctoral Fellow, Harvard Institutes of Medicine, Boston, MA, USA
2000-2004 Associate Research Scientist, University of Regensburg, Institute of Clinical Chemistry and Laboratory Medicine, Germany
2004-2006 Assistant Professor, University of Regensburg, Institute of Clinical Chemistry and Laboratory Medicine, Germany
2006- Associate Professor and Group Leader, University of Regensburg, Institute of Human Genetic, Germany
2010- ProRetina Foundation Professor

Documents

CV of Thomas Langmann [pdf]

Scientifc Interest

  • Role of microglia in retinal degeneration
  • Immune system of the retina
  • Photoreceptor-specific gene expression
  • Retinitis Pigmentosa

Memberships

  • European Macrophage and Dendritic Cell Society (EMDS)
  • Association for Research in Vision and Ophthalmology (ARVO)
  • Deutsche Gesellschaft für Humangenetik (GfH)
Thomas Langmann
Thomas Langmann

Research Group

Retinal Immunity

[more information]

Contact

University of Regensburg

Institute of Human Genetics
Franz-Josef-Strauss Allee 11
93053 Regensburg
Germany

Phone: +49 (0) 941-944-5423
Fax: +49 (0) 941-944-5402

E-mail:
thomas.langmann[at]klinik.uni-regensburg.de

Website:
http://www-huge.uni-regensburg.de/Forschung/AG_Langmann/AG_Langmann.shtml

Key Publications

  1. Friedrich U, Stöhr H, Hilfinger D, Loenhardt T, Schachner M, Langmann T, Weber BH.
    The Na/K-ATPase is obligatory for membrane anchorage of retinoschisin, the protein involved in the pathogenesis of X-linked juvenile retinoschisis.
    Hum Mol Genet. 2010 Dec 31. [Epub ahead of print]
  2. Karlstetter M, Walczak Y, Weigelt K, Ebert S, Van den Brulle J, Schwer H, Fuchshofer R, Langmann T.
    The novel activated microglia/macrophage WAP domain protein, AMWAP, acts as a counter-regulator of proinflammatory response.
    J Immunol. 2010 Sep 15;185(6):3379-90.
  3. Langmann T, Di Gioia SA, Rau I, Stöhr H, Maksimovic NS, Corbo JC, Renner AB, Zrenner E, Kumaramanickavel G, Karlstetter M, Arsenijevic Y, Weber BH, Gal A, Rivolta C.
    Nonsense mutations in FAM161A cause RP28-associated recessive retinitis pigmentosa.
    Am J Hum Genet. 2010 Sep 10;87(3):376-81.
  4. Corbo JC, Lawrence KA, Karlstetter M, Myers CA, Abdelaziz M, Dirkes W, Weigelt K, Seifert M, Benes V, Fritsche LG, Weber BH, Langmann T.
    CRX ChIP-seq reveals the cis-regulatory architecture of mouse photoreceptors.
    Genome Res. 2010 Nov;20(11):1512-25.
  5. Karlstetter M, Ebert S, Langmann T.
    Microglia in the healthy and degenerating retina: insights from novel mouse models.
    Immunobiology. 2010 Sep-Oct;215(9-10):685-91.
  6. Dirscherl K, Karlstetter M, Ebert S, Kraus D, Hlawatsch J, Walczak Y, Moehle C, Fuchshofer R, Langmann T.
    Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype.
    J Neuroinflammation. 2010 Jan 14;7:3.
  7. Ebert S, Weigelt K, Walczak Y, Drobnik W, Mauerer R, Hume DA, Weber BH, Langmann T.
    Docosahexaenoic acid attenuates microglial activation and delays early retinal degeneration.
    J Neurochem. 2009 Sep;110(6):1863-75.
  8. Langmann T, Lai CC, Weigelt K, Tam BM, Warneke-Wittstock R, Moritz OL, Weber BH.
    CRX controls retinal expression of the X-linked juvenile retinoschisis (RS1) gene.
    Nucleic Acids Res. 2008 Nov;36(20):6523-34.
  9. Ebert S, Schoeberl T, Walczak Y, Stoecker K, Stempfl T, Moehle C, Weber BH, Langmann T.
    Chondroitin sulfate disaccharide stimulates microglia to adopt a novel regulatory phenotype.
    J Leukoc Biol. 2008 Sep;84(3):736-40.
  10. Weigelt K, Ernst W, Walczak Y, Ebert S, Loenhardt T, Klug M, Rehli M, Weber BH, Langmann T.
    Dap12 expression in activated microglia from retinoschisin-deficient retina and its PU.1-dependent promoter regulation.
    J Leukoc Biol. 2007 Dec;82(6):1564-74.

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