You are here: vision-research.eu » People » Research Groups » Netherlands » Roepman, Ronald

Molecular Biology of Ciliopathies

Members of the Roepman lab are currently:

  • Jeroen van Reeuwijk
    (post-doc; Nijmegen ciliopathy database and retinal protein interaction networks);
  • Dorus Mans
    (Post-doc; LCA5, RNAi of ciliary genes and ciliary protein complex assembly);
  • Heleen Arts
    (Post-doc; ciliopathies associated with kidney dysfunction);
  • Karlien Coene
    (PhD student; Proteomics, ciliary protein interaction networks and ciliary function);
  • Ferry Kerste
    (PhD student, co-supervision by dr. Hannie Kremer; Usher syndrome);
  • Stef Letteboer
    (senior research technician; yeast two-hybrid screening, proteomics and ciliary function); Sylvia van Beersum (research technician; lenti-based TAP);
  • Lisette Hetterschijt
    (research technician; retinal protein networks and antibody production);
  • Emine Bolat
    (research technician; RNAi of ciliary genes and ciliary protein complex assembly).

Group Leader

Ronald Roepman
[more information]

Contact

Radboud University Nijmegen Medical Centre

Department of Human Genetics,
Nijmegen Centre for Molecular Life Sciences and Institute for Genetic and Metabolic Disease

PO Box 9101

6500 HB Nijmegen
The Netherlands

Phone: +31-24-3610487
Fax: +31-24-3668752

Email:
R.Roepman[at]antrg.umcn.nl

Websites:
Human Genetics Nijmegen
www.humangenetics.nl
NCMLS

Methodology

  • Yeast two-hybrid screens,
  • (tandem) affinity purification,
  • RNAi,
  • zebrafish studies,
  • immunohistochemistry,
  • GST pull-downs,
  • qPCR,
  • Next-gen sequencing,
  • Gateway cloning

Scientific Cooperations

  • Prof. Dr. Marius Ueffing
    (Institute for Ophthalmic Research; University of Tübingen, Germany)
  • Dr. Hannie Kremer
    (Dept. of Otorhinolaryngology, RUNMC Nijmegen)
  • Prof. Dr. Uwe Wolfrum
    (Dept. of Zoölogy, Joh. Gutenberg University, Mainz, Germany)
  • Dr. Dan Doherty
    (University of Washington, Seattle, USA)
  • Prof. Dr. Nicholas Katsanis
    (Duke University, Durham, USA)

Current Research Projects

  • SYSCILIA - systems biology of cilia and ciliopathies
  • Cilia (mal)function in the retinal system
  • Molecular pathogenesis of LCA5
  • LCA5 gene therapy
  • Pathogenetic mechanisms in Usher syndrome

Research Groups

People

Related Research Groups

connecting cilium
Oops, an error occurred! Code: 20200926000925a805621a
gene modifiers
Oops, an error occurred! Code: 202009260009255e36b8ff
genetics
Oops, an error occurred! Code: 202009260009258256abfd
immunohistochemistry
Oops, an error occurred! Code: 20200926000925ed9c8391
protein structure/function
Oops, an error occurred! Code: 202009260009252c675bf9
proteins encoded by disease genes
Oops, an error occurred! Code: 202009260009252f90c294
proteomics
Oops, an error occurred! Code: 2020092600092552a2fa69
retinal degenerations: cell biology
Oops, an error occurred! Code: 2020092600092524ca7341
retinal degenerations: hereditary
Oops, an error occurred! Code: 202009260009251361b1a7
transgenics/knock-outs
Oops, an error occurred! Code: 20200926000925af8a6093
retinal ciliopathies
Oops, an error occurred! Code: 20200926000925477afbc8
cilia
Oops, an error occurred! Code: 2020092600092579e8abe4
systems biology
Oops, an error occurred! Code: 202009260009252b0126f9
Usher syndrome
Oops, an error occurred! Code: 2020092600092523b043d6
Joubert syndrome
Oops, an error occurred! Code: 20200926000925c90efb9f