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Molecular Biology of Ciliopathies

Members of the Roepman lab are currently:

  • Jeroen van Reeuwijk
    (post-doc; Nijmegen ciliopathy database and retinal protein interaction networks);
  • Dorus Mans
    (Post-doc; LCA5, RNAi of ciliary genes and ciliary protein complex assembly);
  • Heleen Arts
    (Post-doc; ciliopathies associated with kidney dysfunction);
  • Karlien Coene
    (PhD student; Proteomics, ciliary protein interaction networks and ciliary function);
  • Ferry Kerste
    (PhD student, co-supervision by dr. Hannie Kremer; Usher syndrome);
  • Stef Letteboer
    (senior research technician; yeast two-hybrid screening, proteomics and ciliary function); Sylvia van Beersum (research technician; lenti-based TAP);
  • Lisette Hetterschijt
    (research technician; retinal protein networks and antibody production);
  • Emine Bolat
    (research technician; RNAi of ciliary genes and ciliary protein complex assembly).

Group Leader

Ronald Roepman
[more information]

Contact

Radboud University Nijmegen Medical Centre

Department of Human Genetics,
Nijmegen Centre for Molecular Life Sciences and Institute for Genetic and Metabolic Disease

PO Box 9101

6500 HB Nijmegen
The Netherlands

Phone: +31-24-3610487
Fax: +31-24-3668752

Email:
R.Roepman[at]antrg.umcn.nl

Websites:
Human Genetics Nijmegen
www.humangenetics.nl
NCMLS

Methodology

  • Yeast two-hybrid screens,
  • (tandem) affinity purification,
  • RNAi,
  • zebrafish studies,
  • immunohistochemistry,
  • GST pull-downs,
  • qPCR,
  • Next-gen sequencing,
  • Gateway cloning

Scientific Cooperations

  • Prof. Dr. Marius Ueffing
    (Institute for Ophthalmic Research; University of Tübingen, Germany)
  • Dr. Hannie Kremer
    (Dept. of Otorhinolaryngology, RUNMC Nijmegen)
  • Prof. Dr. Uwe Wolfrum
    (Dept. of Zoölogy, Joh. Gutenberg University, Mainz, Germany)
  • Dr. Dan Doherty
    (University of Washington, Seattle, USA)
  • Prof. Dr. Nicholas Katsanis
    (Duke University, Durham, USA)

Current Research Projects

  • SYSCILIA - systems biology of cilia and ciliopathies
  • Cilia (mal)function in the retinal system
  • Molecular pathogenesis of LCA5
  • LCA5 gene therapy
  • Pathogenetic mechanisms in Usher syndrome

Research Groups

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