You are here: vision-research.eu » People » Research Groups » Netherlands » Roepman, Ronald

Molecular Biology of Ciliopathies

Members of the Roepman lab are currently:

  • Jeroen van Reeuwijk
    (post-doc; Nijmegen ciliopathy database and retinal protein interaction networks);
  • Dorus Mans
    (Post-doc; LCA5, RNAi of ciliary genes and ciliary protein complex assembly);
  • Heleen Arts
    (Post-doc; ciliopathies associated with kidney dysfunction);
  • Karlien Coene
    (PhD student; Proteomics, ciliary protein interaction networks and ciliary function);
  • Ferry Kerste
    (PhD student, co-supervision by dr. Hannie Kremer; Usher syndrome);
  • Stef Letteboer
    (senior research technician; yeast two-hybrid screening, proteomics and ciliary function); Sylvia van Beersum (research technician; lenti-based TAP);
  • Lisette Hetterschijt
    (research technician; retinal protein networks and antibody production);
  • Emine Bolat
    (research technician; RNAi of ciliary genes and ciliary protein complex assembly).

Group Leader

Ronald Roepman
[more information]

Contact

Radboud University Nijmegen Medical Centre

Department of Human Genetics,
Nijmegen Centre for Molecular Life Sciences and Institute for Genetic and Metabolic Disease

PO Box 9101

6500 HB Nijmegen
The Netherlands

Phone: +31-24-3610487
Fax: +31-24-3668752

Email:
R.Roepman[at]antrg.umcn.nl

Websites:
Human Genetics Nijmegen
www.humangenetics.nl
NCMLS

Methodology

  • Yeast two-hybrid screens,
  • (tandem) affinity purification,
  • RNAi,
  • zebrafish studies,
  • immunohistochemistry,
  • GST pull-downs,
  • qPCR,
  • Next-gen sequencing,
  • Gateway cloning

Scientific Cooperations

  • Prof. Dr. Marius Ueffing
    (Institute for Ophthalmic Research; University of Tübingen, Germany)
  • Dr. Hannie Kremer
    (Dept. of Otorhinolaryngology, RUNMC Nijmegen)
  • Prof. Dr. Uwe Wolfrum
    (Dept. of Zoölogy, Joh. Gutenberg University, Mainz, Germany)
  • Dr. Dan Doherty
    (University of Washington, Seattle, USA)
  • Prof. Dr. Nicholas Katsanis
    (Duke University, Durham, USA)

Current Research Projects

  • SYSCILIA - systems biology of cilia and ciliopathies
  • Cilia (mal)function in the retinal system
  • Molecular pathogenesis of LCA5
  • LCA5 gene therapy
  • Pathogenetic mechanisms in Usher syndrome

Research Groups

People

Related Research Groups

connecting cilium
Oops, an error occurred! Code: 20200125012714f8040a0b
gene modifiers
Oops, an error occurred! Code: 20200125012714c7960e66
genetics
Oops, an error occurred! Code: 20200125012714e6b85f51
immunohistochemistry
Oops, an error occurred! Code: 2020012501271462a3f08b
protein structure/function
Oops, an error occurred! Code: 20200125012714a2324869
proteins encoded by disease genes
Oops, an error occurred! Code: 20200125012714638c6539
proteomics
Oops, an error occurred! Code: 2020012501271476ff1596
retinal degenerations: cell biology
Oops, an error occurred! Code: 20200125012714489d23cc
retinal degenerations: hereditary
Oops, an error occurred! Code: 202001250127145bd15fb6
transgenics/knock-outs
Oops, an error occurred! Code: 20200125012714099f1aa3
retinal ciliopathies
Oops, an error occurred! Code: 202001250127143d13cb7a
cilia
Oops, an error occurred! Code: 20200125012714a3a75621
systems biology
Oops, an error occurred! Code: 20200125012714a53297ff
Usher syndrome
Oops, an error occurred! Code: 202001250127140870733d
Joubert syndrome
Oops, an error occurred! Code: 2020012501271419071301