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The Investigation of Acute Optic Neuritis: a Review and Proposed Protocol

Optic neuritis is frequently but not always associated with multiple sclerosis (MS), and patients who present with optic neuritis will want to know about their risk of developing MS. This Review on established and emerging diagnostic tools proposes a consensus on the investigation of patients with suspected optic neuritis in both standard care and research.

Dr Axel Petzold
Dr Axel Petzold

Optic neuritis is an inflammatory optic neuropathy that is frequently- but not always - associated with multiple sclerosis (MS). Despite recent developments in laboratory, imaging and electrophysiological techniques, no consensus guidelines have yet been formulated for the diagnostic work-up in patients presenting with optic neuritis.

In this Review, published in Nature Reviews Neurology, Dr Petzold (Department of Neuroinflammation, UCL Institute of Neurology) and colleagues contribute to the development of such a consensus by proposing an investigation protocol for optic neuritis.

The aims are to aid recognition of patients at risk of severe visual loss, to contribute to future attempts at classification of optic neuritis, and to provide end points for clinical studies.

Original Publication:

The investigation of acute optic neuritis: a review and proposed protocol

Axel Petzold, Mike P. Wattjes, Fiona Costello, Jose Flores-Rivera, Clare L. Fraser, Kazuo Fujihara, Jacqueline Leavitt, Romain Marginier, Friedemann Paul, Sven Schippling, Christian Sindic, Pablo Villoslada, Brian Weinshenker & Gordon T. Plant

http://www.nature.com/nrneurol/journal/vaop/ncurrent/full/nrneurol.2014.108.html

Contact

Dr Axel Petzold

UCL Institute of Neurology
Queen Square, London, WC1N 3BG
United Kingdom

E-mail: a.petzold[at]ucl.ac.uk

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